1.14.13.154 malfunction an Saccharopolyspora erythraea strain disrupted in eryK no longer produces erythromycin A but accumulates the B and D forms of the antibiotic 715331 1.14.13.154 physiological function the enzyme is responsible for the C-12 hydroxylation of the macrolactone ring, one of the last steps in erythromycin biosynthesis 715331