3.4.24.79	malfunction	down-regulation of enzyme expression and secretion decreases tumor growth after implanted in vivo	735072	
3.4.24.79	malfunction	enzyme concentrations are reduced in the first trimester of pregnancies affected by fetal Down's syndrome	735323	
3.4.24.79	physiological function	pregnancy-associated plasma protein-A (PAPP-A) acts to enhance tumor growth in vivo. Overexpression of PAPP-A favored development of mature tumor vasculature. PAPP-A proteolytic activity enhances the tumorigenic potential of ovarian cancer cells	719372	
3.4.24.79	physiological function	pregnancy-associated plasma protein-A (PAPP-A) increases local insulin-like growth factor-I bioavailability through cleavage of inhibitory insulin-like growth factor binding protein. Expression of human PAPP-A localized to arterial smooth muscle accelerates lesion progression in a mouse model of atherosclerosis	718547	
3.4.24.79	physiological function	protein secretion is required for pregnancy-associated plasma protein-A to promote lung cancer growth and progression in vivo	735072	
3.4.24.79	physiological function	the enzyme can act as an autocrine/paracrine regulator of insulin-like growth factor action	735323	
3.4.24.79	physiological function	the enzyme induces tissue factor expression in epithelial cells through the activation of Akt/nuclear factor-kappaB axis	754523