2.4.2.12	malfunction	enzyme inhibition induces NAD depletion in various mouse organs but selectively causes dramatic atrophy of the spleen red pulp	736227	
2.4.2.12	malfunction	enzyme inhibition is responsible for ATP depletion, metabolic perturbation, and subsequent tumor growth inhibition	736436	
2.4.2.12	malfunction	homozygous enzyme knockout results in lethality at an early stage of mouse embryonic development and death within 5-10 days in adult mice accompanied by a 25.24% body weight loss	759022	
2.4.2.12	malfunction	implicated in the pathogenesis of a number of human diseases or conditions such as acute lung injury, aging, atherosclerosis, cancer, diabetes, rheumatoid arthritis and sepsis	722560	
2.4.2.12	malfunction	partial deletion of the enzyme facilitates high-fat diet-induced atrial fibrillation through increased diastolic calcium leaks	759372	
2.4.2.12	malfunction	reduced enzyme expression increases endothelial cell susceptibility to tumor necrosis factor-alpha-induced apoptosis as reflected by PARP-1 cleavage and caspase-3 activation	758625	
2.4.2.12	metabolism	enhanced enzyme expression increases cellular NAD+ concentration no more than 2fold	760043	
2.4.2.12	metabolism	enzyme-mediated NAD biosynthesis may modify cocaine behavioral effects through sirtuin 1. The enzyme regulates cocaine reward through the NAD/sirtuin 1 pathway	759157	
2.4.2.12	metabolism	the enzyme catalyzes the rate-limiting step in NAD synthesis	759503	
2.4.2.12	physiological function	cardiac-specific overexpression of Nampt in transgenic mice increases NAD+ content in the heart, prevents downregulation of Nampt, and reduces the size of myocardial infarction and apoptosis in response to prolonged ischemia and ischemia/reperfusion. Upregulation of Nampt significantly increases NAD+ and ATP concentrations, whereas downregulation of Nampt significantly decreases them. Expression of Nampt in the heart is significantly decreased by ischemia, ischemia/reperfusion and pressure overload. Downregulation of Nampt increases caspase 3 cleavage, cytochrome c release, and TUNEL-positive cells, which are inhibited in the presence of Bcl-xL, but do not increase hairpin 2-positive cells, suggesting that endogenous Nampt negatively regulates apoptosis but not necrosis. Downregulation of Nampt also impairs autophagic flux	703243	
2.4.2.12	physiological function	enzyme activity is essential for survival of resting lymphocytes	736227	
2.4.2.12	physiological function	enzyme overexpression serves to reduce degrees of tumor necrosis factor-alpha-induced endothelial cell apoptosis	758625	
2.4.2.12	physiological function	enzyme upregulation in human pulmonary artery endothelial cells is associated with pulmonary arterial hypertension progression and pulmonary vascular remodeling	760186	
2.4.2.12	physiological function	growth factor, cytokine and nicotinamide phosphoribosyltransferase	722560	
2.4.2.12	physiological function	nicotinamide phosphoribosyltransferase is a rate-limiting enzyme in the NAD+ salvage pathway and plays an important role in controlling the level of NAD+ and the activity of Sirt1 in the heart and the cardiomyocytes therein. The enzyme protects the heart from ischemia and reperfusion injury by stimulating Sirt1 and autophagy	736003	
2.4.2.12	physiological function	required for de novo lipogenesis in tumor cells	723576	
2.4.2.12	physiological function	the enzyme catalyzes the first rate-limiting step in converting nicotinamide to NAD+, essential for cellular metabolism, energy production, and DNA repair	736436	
2.4.2.12	physiological function	the enzyme inhibits Rantes-induced Ca2+-rises and Rantes-induced migration in melanoma cells	759035	
2.4.2.12	physiological function	the enzyme is an essential gene for adult mouse survival. The enzyme is involved in key basic cellular functions such as transcription, translation, cell signaling, and fundamental metabolism	759022	
2.4.2.12	physiological function	the enzyme is essential for early embryonic development	736091	
2.4.2.12	physiological function	the enzyme is involved in cancer	735872	
2.4.2.12	physiological function	the up-regulation of enzyme in cancer affects cell growth and survival, immune responses and inflammation, signaling, redox reactions and metabolic pathways, DNA repair and epigenetic regulation of gene expression, and invasiveness properties of tumor	760200