2.1.1.160	malfunction	post-transcriptional silencing of caffeine synthase mRNA leads to reduced caffeine content in tea leaves	720717	
2.1.1.160	metabolism	caffeine synthase catalyzes the S-adenosyl-L-methionine-dependent N-3- and N-1-methylation of the purine base to form caffeine, the last step in the purine alkaloid biosynthetic pathway. Pathways for the biosynthesis of caffeine and phenylpropanoids, overview	721123	
2.1.1.160	metabolism	caffeine synthase is a bifunctional enzyme that catalyzes the last two steps of caffeine biosynthesis in tea as 7-N-methylxanthine methyltransferase and 3,7-dimethylxanthine methyltransferase	720717	
2.1.1.160	metabolism	caffeine synthesis and degradation in tea is under developmental and seasonal regulation	700125	
2.1.1.160	metabolism	the enzyme catalyzes the second and third step in caffeine biosynthesis, pathway overview	721124	
2.1.1.160	additional information	regulation of TCS gene expression	721123