1.1.2.4	malfunction	under methylglyoxal treatment, silencing of OsD-LDH in rice results in the accumulation of methylglyoxal and D-lactate, the decrease of reduced glutathione in leaves, and ultimately severe growth inhibition. The silencing of OsD-LDH does not affect the growth under photorespiration conditions	
1.1.2.4	metabolism	prostate cancer cells metabolize D-lactate inside mitochondria via a D-lactate dehydrogenase which is more active and highly expressed than in normal cells. D-Lactate can enter prostate mitochondria and cause the export of newly synthesized malate in a carrier-mediated manner, with the rate of malate efflux from mitochondria being twofold higher in cancer compared to healthy cells, overview	
1.1.2.4	metabolism	the enzyme participates in methylglyoxal metabolism by affecting the activity of the glyoxalase system and aldoketo reductases	
1.1.2.4	physiological function	participates in the methylglyoxal pathway	
1.1.2.4	physiological function	the mitochondrial D-lactate dehydrogenase, a membrane flavoprotein, from both cancer (PC-3) and normal (PNT1A) prostate cells can metabolize D-lactate in an energy competent manner	
1.1.2.4	physiological function	transgenic plants overexpressing both D-LDH and cytochrome c have enhanced capacity to detoxify D-lactate and methylglyoxal, indicating that both proteins can be limiting factors in the detoxification process