2.4.2.53 additional information pmrF expression is independent of polymyxin resistance proteins PmrA-PmrB in Yersinia pseudotuberculosis, with the response regulator PhoP interacting directly with the pmrF operon promoter region 709838 2.4.2.53 up low Mg2+/Ca2+ concentration of 1 mM and a pH decrease from 8 to 6 both induce polymyxin resistance. Transcription of the pmrF operon in Yersinia pseudotuberculosis increases accordingly, by a factor of 7 and 2.5 for the Mg2+/Ca2+ ion starvation and acidic pH conditions, respectively 709838