3.4.24.B6	down	loss and siRNA-mediated silencing of Runx2 in ameloblast-lineage cells decreases ODAM expression, resulting in downregulation of MMP-20 expression	712555	
3.4.24.B6	additional information	Mmp20 expression levels must be within a specific range for normal enamel development to occur. Creation of a normally thick enamel layer may occur over a wider range of Mmp20 expression levels, but acquisition of normal enamel hardness has a narrower range	735135	
3.4.24.B6	up	increased expression of ODAM and Runx2 augments MMP-20 expression, and both TGF-beta1 and BMP-2 up-regulate Runx2 expression. TGF-beta1 promotes MMP-20 expression in ameloblasts	712555	
3.4.24.B6	up	transforming growth factor-beta1, TGF-beta1, prominently induces MMP20 expression in ameloblast-lineage cells	710860