3.4.24.82 up disruption of chondrocyte hyaluran receptor CD44-hyaluran interactions with hyaluran oligosaccharides induces the transcription of endopeptidases ADAMTS-4 and ADAMTS-5 in a time- and dose-dependent manner 733229 3.4.24.82 up enzyme expression is increased in mice with aortic aneurysm and dissection 755457 3.4.24.82 up interleukin-1 and TNF-alpha upregulate ADAMTS-4 mRNA expression 720093