3.4.22.53	down	0.1 mM indomethacin and 0.1 mM NS-398 decrease expression of calpain 2 in total membrane fractions and in plasma membranes by 70%, while 0.001 mM SC-560 decreases expression of calpain 2 in total membrane fractions and in plasma membranes by 30%	717669	
3.4.22.53	down	a 6-day treatment with siRNA results in an about 60% reduction of calpain 2 protein levels in R1 cells	709126	
3.4.22.53	down	inhibition of MEK1/2 using PD98059 reduces the expression of calpain-2	707902	
3.4.22.53	down	m-calpain expression levels in aorta in siRNAtreated mice are significantly diminished by 63.5% in comparison to those in control RNA-transfected mice with no alteration of m-calpain or beta-actin expression	708018	
3.4.22.53	up	a heat stress stimulus induces massive germ cells apoptosis, which is associated with an increase in the levels of mRNA encoding calpain 2	709241	
3.4.22.53	up	brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation	709641	
3.4.22.53	up	calpain 2 expression levels increase throughout stem cell differentiation	732688	
3.4.22.53	up	calpain 2 is upregulated in mouse pancreas exposed to caerulein for 12 h	707385	
3.4.22.53	up	calpain activation occurs during reperfusion, but only after intracellular pH normalization, and is not prevented by inhibiting its translocation during ischemia with methyl-beta-cyclodextrin	709566	
3.4.22.53	up	endoplasmic reticulum stress stimulates calpain II activation, interleukin-13 enhances endoplasmic reticulum stress-regulated calpain activation and calpain-II expression in lipopolysaccaride-activated microglia	708062