1.14.17.1	down	A53T Tg mice that express human A53T variant alpha-synuclein under the direction of the mouse prion protein promoter show decreased DBH expression. A53T Tg mice exhibit anxiety-like behaviors and abnormal adaptive responses following the repeated immobilization stress	744851	
1.14.17.1	down	alpha-SYN enters the nucleus and binds directly to the DBH promoter region. alpha-Syn atteniúates the forskolin-induced DBH upregulation in SK-N-BE(2) cells	744851	
1.14.17.1	down	Egr1 reduces DBH promoter activity, reduction occurrs as early as 4 h and reaches maximal inhibition 16-40 h after transfection. Egr1 also reduces the expression of endogenous DBH mRNA and the induction of DBH promoter activity by cAMP. The first 247, but not 200, nucleotides of DBH promoter are sufficient for suppression	702956	
1.14.17.1	down	enzyme downregulation by LvDBH-dsRNA	744950	
1.14.17.1	down	LvDBH expression is silenced in thoracic ganglia, haemocytes and hepatopancreas of shrimp by treatment with LvDBH-dsRNA for 3 days, a decrease of DBH contents in haemocytes accompanied by decreased levels of norepinephrine and dopamine in hemolymph are observed. LvDBH expressions in thoracic ganglia, haemocytes, and hepatopancreas of shrimp transferred from 28°C to 20°C for 30 min are significant higher than those held at 28°C, hypothermal stress reduces the expression of LvDBH	744949	
1.14.17.1	down	transfection of shRNAs specific to Phox2a or Phox2b genes significantly reduces mRNA and protein levels of DBH after shutdown of endogenous Phox2, which is accompanied by a decreased [(3)H]norepinephrine uptake. Reduced DBH expression caused by the shRNA specific to Phox2a can be reversed by transfection with Phox2b cDNA and vice versa. Cotransfection with both shRNAs specific to Phox2a and Phox2b genes does not further reduce mRNA and protein levels of DBH	705254	
1.14.17.1	up	both in adrenal medulla and stellate ganglia, single immobilization significantly increases DBH mRNA and protein levels both in wild-type and corticotropin-releasing hormone knockout mice	701704	
1.14.17.1	up	Cu-negative samples have significantly higher DBM activity than Cu-positive samples in both adrenal glands (2.4fold) and medulla oblongata/pons (0.9fold), but not vas deferens. No correlation between higher DBM mRNA and lower noradrenaline in Cu-negative tissues	702945	
1.14.17.1	up	DBM protein abundance in adrenal glands is higher in the Cu-negative samples compared with Cu-positive samples	702945	
1.14.17.1	up	enzyme expression is highest in 5-weeks-old rats	727633