6.3.2.17	 Arabidopsis plastidial folylpolyglutamate synthetase is required for nitrogen metabolism under nitrate-limited condition in darkness	Arabidopsis thaliana	
6.3.2.17	 Arabidopsis plastidial folylpolyglutamate synthetase is required for nitrogen metabolism under nitrate-limited condition in darkness	Arabidopsis thaliana Col-0	
6.3.2.17	 Arabidopsis plastidial folylpolyglutamate synthetase is required for seed reserve accumulation and seedling establishment in darkness	Arabidopsis thaliana	
6.3.2.17	 Effect of folylpolyglutamate synthase A22G polymorphism on the risk and survival of patients with acute lymphoblastic leukemia	Homo sapiens	
6.3.2.17	 Effect of the polymorphism of folylpolyglutamate synthetase on treatment of high-dose methotrexate in pediatric patients with acute lymphocytic leukemia	Homo sapiens	
6.3.2.17	 Effects of folylpolyglutamate synthase modulation on global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells	Homo sapiens	
6.3.2.17	 Folylpoly-gamma-glutamate synthetase	 A key determinant of folate homeostasis and antifolate resistance in cancer	Rattus norvegicus	
6.3.2.17	 Folylpoly-gamma-glutamate synthetase	 A key determinant of folate homeostasis and antifolate resistance in cancer	Escherichia coli	
6.3.2.17	 Folylpoly-gamma-glutamate synthetase	 A key determinant of folate homeostasis and antifolate resistance in cancer	Lacticaseibacillus casei	
6.3.2.17	 Folylpoly-gamma-glutamate synthetase	 A key determinant of folate homeostasis and antifolate resistance in cancer	Mus musculus	
6.3.2.17	 Folylpoly-gamma-glutamate synthetase	 A key determinant of folate homeostasis and antifolate resistance in cancer	Homo sapiens	
6.3.2.17	 Folylpoly-gamma-glutamate synthetase	 A key determinant of folate homeostasis and antifolate resistance in cancer	Cricetulus griseus	
6.3.2.17	 Folylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis	Homo sapiens	
6.3.2.17	 Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance	Homo sapiens	
6.3.2.17	 Humanizing mouse folate metabolism	 conversion of the dual-promoter mouse folylpolyglutamate synthetase gene to the human single-promoter structure	Mus musculus	
6.3.2.17	 Loss of function of folylpolyglutamate synthetase 1 reduces lignin content and improves cell wall digestibility in Arabidopsis	Arabidopsis thaliana	
6.3.2.17	 Loss of function of folylpolyglutamate synthetase 1 reduces lignin content and improves cell wall digestibility in Arabidopsis	Arabidopsis thaliana Col-0	
6.3.2.17	 Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates	Cricetulus griseus	
6.3.2.17	 Mutation screening and association study of the folylpolyglutamate synthetase (FPGS) gene with susceptibility to childhood acute lymphoblastic leukemia	Homo sapiens	
6.3.2.17	 Sex differences in mRNA expression of reduced folate carrier-1, folypolyformyl glutamate synthase, and gamma-glutamyl hydrolase in a healthy Japanese population	Homo sapiens	
6.3.2.17	 The maize brown midrib4 (bm4) gene encodes a functional folylpolyglutamate synthase	Zea mays	
6.3.2.17	A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria	Plasmodium falciparum	
6.3.2.17	A domino effect in antifolate drug action in Escherichia coli	Escherichia coli	
6.3.2.17	Activation of mammalian folylpolyglutamate synthetase by sodium bicarbonate	Homo sapiens	
6.3.2.17	Activation of mammalian folylpolyglutamate synthetase by sodium bicarbonate	Rattus norvegicus	
6.3.2.17	An endogenous inhibitor of folylpolyglutamate synthetase in Neurospora crassa	Bos taurus	
6.3.2.17	An endogenous inhibitor of folylpolyglutamate synthetase in Neurospora crassa	Escherichia coli	
6.3.2.17	An endogenous inhibitor of folylpolyglutamate synthetase in Neurospora crassa	Neurospora crassa	
6.3.2.17	An endogenous inhibitor of folylpolyglutamate synthetase in Neurospora crassa	Pisum sativum	
6.3.2.17	Analysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells	Homo sapiens	
6.3.2.17	Bacterial folylpoly(gamma-glutamate) synthase-dihydrofolate synthase	Corynebacterium sp.	
6.3.2.17	Bacterial folylpoly(gamma-glutamate) synthase-dihydrofolate synthase	Escherichia coli	
6.3.2.17	Bacterial folylpoly(gamma-glutamate) synthase-dihydrofolate synthase	Lacticaseibacillus casei	
6.3.2.17	Binding of ATP as well as tetrahydrofolate induces conformational changes in Lactobacillus casei folylpolyglutamate synthetase in solution	Lacticaseibacillus casei	
6.3.2.17	Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines	Homo sapiens	
6.3.2.17	Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition	Plasmodium falciparum	
6.3.2.17	Characterization of the function of mammalian folylpolyglutamate synthetase (FPGS)	Mus musculus	
6.3.2.17	Concentration-dependent processivity of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase	Homo sapiens	
6.3.2.17	Corynebacterium species folylpoly-gamma-glutamate synthetase	Corynebacterium sp.	
6.3.2.17	Disruption of cytoplasmic and mitochondrial folylpolyglutamate synthetase activity in Saccharomyces cerevisiae	Saccharomyces cerevisiae	
6.3.2.17	Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers	Homo sapiens	
6.3.2.17	DL-3,3-Difluoroglutamate: an enhancer of folylpolyglutamate elongation	Rattus norvegicus	
6.3.2.17	DL-beta,beta-Difluoroglutamic acid mediates position-dependent enhancement or termination of pteroylpoly(glutamate)synthesis catalyzed by folylpolyglutamate synthetase	Homo sapiens	
6.3.2.17	DL-beta,beta-Difluoroglutamic acid mediates position-dependent enhancement or termination of pteroylpoly(glutamate)synthesis catalyzed by folylpolyglutamate synthetase	Rattus norvegicus	
6.3.2.17	Docking studies and ligand recognition in folylpolyglutamate synthetase	Lacticaseibacillus casei	
6.3.2.17	Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate	Homo sapiens	
6.3.2.17	Enzymatic synthesis and function of folylpolyglutamates	Bacteria	
6.3.2.17	Enzymatic synthesis and function of folylpolyglutamates	Corynebacterium sp.	
6.3.2.17	Enzymatic synthesis and function of folylpolyglutamates	eukaryota	
6.3.2.17	Enzymatic synthesis and function of folylpolyglutamates	Neurospora crassa	
6.3.2.17	Escherichia coli FolC structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy	Escherichia coli	
6.3.2.17	Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate)synthetase and determination of its primary structure	Homo sapiens	
6.3.2.17	Folate analogues as substrates of mammalian folylpolyglutamate synthetase	Bos taurus	
6.3.2.17	Folate analogues as substrates of mammalian folylpolyglutamate synthetase	Rattus norvegicus	
6.3.2.17	Folate-binding triggers the activation of folylpolyglutamate synthetase	Lacticaseibacillus casei	
6.3.2.17	Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells	Cricetulus griseus	
6.3.2.17	Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells	Corynebacterium sp.	
6.3.2.17	Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells	Escherichia coli	
6.3.2.17	Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells	Enterococcus faecalis	
6.3.2.17	Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells	Lacticaseibacillus casei	
6.3.2.17	Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells	Neurospora crassa	
6.3.2.17	Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells	Rattus norvegicus	
6.3.2.17	Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells	Sus scrofa	
6.3.2.17	Folylpoly-gamma-glutamate synthetase	Saccharomyces cerevisiae	
6.3.2.17	Folylpoly-gamma-glutamate synthetase	Corynebacterium sp.	
6.3.2.17	Folylpoly-gamma-glutamate synthetase	Escherichia coli	
6.3.2.17	Folylpoly-gamma-glutamate synthetase	eukaryota	
6.3.2.17	Folylpoly-gamma-glutamate synthetase	Homo sapiens	
6.3.2.17	Folylpoly-gamma-glutamate synthetase	Lacticaseibacillus casei	
6.3.2.17	Folylpoly-gamma-glutamate synthetase	Sus scrofa	
6.3.2.17	Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase. Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product	Escherichia coli	
6.3.2.17	Folylpoly-gamma-glutamate synthetase: generation of isozymes and the role in one carbon metabolism and antifolate cytotoxicity	Homo sapiens	
6.3.2.17	Folylpoly-gamma-glutamate synthetases: properties and regulation	Bacteria	
6.3.2.17	Folylpoly-gamma-glutamate synthetases: properties and regulation	Cricetulus griseus	
6.3.2.17	Folylpoly-gamma-glutamate synthetases: properties and regulation	Corynebacterium sp.	
6.3.2.17	Folylpoly-gamma-glutamate synthetases: properties and regulation	Enterococcus faecalis	
6.3.2.17	Folylpoly-gamma-glutamate synthetases: properties and regulation	Lacticaseibacillus casei	
6.3.2.17	Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity	Homo sapiens	
6.3.2.17	Folylpolyglutamate synthase from higher plants	Homo sapiens	
6.3.2.17	Folylpolyglutamate synthase from higher plants	Pisum sativum	
6.3.2.17	Folylpolyglutamate synthetase activities of Neurospora	Neurospora crassa	
6.3.2.17	Folylpolyglutamate synthetase from beef liver: assay, stabilization, and characterization	Bos taurus	
6.3.2.17	Folylpolyglutamate synthetase from beef liver: purification and some properties	Bos taurus	
6.3.2.17	Folylpolyglutamate synthetase gene transcription is regulated by a multiprotein complex that binds the TEL-AML1 fusion in acute lymphoblastic leukemia	Homo sapiens	
6.3.2.17	Higher plant folylpolyglutamate synthetase. I. Purification, stability and reaction requirements of the enzyme from pea seedlings	Pisum sativum	
6.3.2.17	Higher plant folylpolyglutamate synthetase. II. Some major catalytic properties of the enzyme from Pisum sativum	Pisum sativum	
6.3.2.17	Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy	Homo sapiens	
6.3.2.17	Human cytosolic and mitochondrial folylpolyglutamate synthetase are electrophoretically distinct. Expression in antifolate-sensitive and -resistant human cell lines	Homo sapiens	
6.3.2.17	Human cytosolic folylpoly-gamma-glutamate synthase	Homo sapiens	
6.3.2.17	Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists	Oryctolagus cuniculus	
6.3.2.17	Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists	Homo sapiens	
6.3.2.17	Identification and characterization of genetic variation in the folylpolyglutamate synthase gene	Homo sapiens	
6.3.2.17	Identification of three key active site residues in the C-terminal domain of human recombinant folylpoly-gamma-glutamate synthetase by site-directed mutagenesis	Homo sapiens	
6.3.2.17	Improved methods for the preparation of [(3)H]folate polyglutamates: biosynthesis with Lactobacillus casei and enzymatic synthesis with Escherichia coli folylpolyglutamate synthetase	Escherichia coli	
6.3.2.17	Inhibition of human folylpolyglutamate synthetase by diastereomeric phosphinic acid mimics of the tetrahedral intermediate	Homo sapiens	
6.3.2.17	Inhibition of human liver folylpolyglutamate synthetase by non-gamma-glutamylatable antifolate analogs	Homo sapiens	
6.3.2.17	Isolation of dihydrofolate and folylpolyglutamate synthetase activities from Neurospora	Neurospora crassa	
6.3.2.17	Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines	Homo sapiens	
6.3.2.17	Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines	Mus musculus	
6.3.2.17	Mammalian folyl polyglutamate synthetase: Partial purification and properties of the mouse liver enzyme	Mus musculus	
6.3.2.17	Mammalian folylpoly-gamma-glutamate synthetase. 1. Purification and general properties of the hog liver enzyme	Sus scrofa	
6.3.2.17	Mammalian folylpoly-gamma-glutamate synthetase. 2. Substrate specificity and kinetic properties	Sus scrofa	
6.3.2.17	Mammalian folylpoly-gamma-glutamate synthetase. 3. Specificity of folate analogues	Sus scrofa	
6.3.2.17	Mammalian folylpoly-gamma-glutamate synthetase. 4. In vitro and in vivo metabolism of folates and analogues and regulation of folate homeostasis	Cricetulus griseus	
6.3.2.17	Mammalian folylpoly-gamma-glutamate synthetase. 4. In vitro and in vivo metabolism of folates and analogues and regulation of folate homeostasis	Sus scrofa	
6.3.2.17	Measurement of folylpolyglutamate synthetase in mammalian tissues	Cricetulus griseus	
6.3.2.17	Measurement of folylpolyglutamate synthetase in mammalian tissues	Mus musculus	
6.3.2.17	Measurement of folylpolyglutamate synthetase in mammalian tissues	Rattus norvegicus	
6.3.2.17	Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos	Mus musculus	
6.3.2.17	Molecular analysis of murine leukemia cell lines resistant to 5,10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase	Mus musculus	
6.3.2.17	Molecular basis for decreased folylpoly-gamma-glutamate synthetase expression in a methotrexate resistant CCRF-CEM mutant cell line	Homo sapiens	
6.3.2.17	Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors	Mus musculus	
6.3.2.17	Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site	Escherichia coli	
6.3.2.17	Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site	Lacticaseibacillus casei	
6.3.2.17	Mutagenesis of the folC gene encoding folylpolyglutamate synthetase-dihydrofolate synthetase in Escherichia coli	Escherichia coli	
6.3.2.17	Mutation of an essential glutamate residue in folylpolyglutamate synthetase and activation of the enzyme by pteroate binding	Escherichia coli	
6.3.2.17	Mutation of an essential glutamate residue in folylpolyglutamate synthetase and activation of the enzyme by pteroate binding	Lacticaseibacillus casei	
6.3.2.17	Mutation of Gly51 to serine in the P-loop of Lactobacillus casei folylpolyglutamate synthetase abolishes activity by altering the conformation of two adjacent loops	Lacticaseibacillus casei	
6.3.2.17	p161NK4a gene promoter hypermethylation in mucosa as a prognostic factor for patients with colorectal cancer	Homo sapiens	
6.3.2.17	Potent inhibition of human folylpolyglutamate synthetase by a phosphinic acid mimic of the tetrahedral reaction intermediate	Homo sapiens	
6.3.2.17	Pteroylpoly(gamma-glutamate) synthesis by Corynebacterium species. Purification and properties of folylpoly(gamma-glutamate) synthetase	Corynebacterium sp.	
6.3.2.17	Pteroylpoly(gamma-glutamate) synthesis by Corynebacterium species. Studies on the mechanism of folylpoly(gamma-glutamate) synthetase	Corynebacterium sp.	
6.3.2.17	Purification and characteristics of recombinant human folylpoly-gamma-glutamate synthetase expressed at high levels in insect cells	Homo sapiens	
6.3.2.17	Purification and characterization of folylpolyglutamate synthetase (FPGS) from cultured cells of Datura innoxia	Datura inoxia	
6.3.2.17	Purification and characterization of folylpolyglutamate synthetase from Lactobacillus casei and hog liver	Lacticaseibacillus casei	
6.3.2.17	Purification and characterization of folylpolyglutamate synthetase from Lactobacillus casei and hog liver	Sus scrofa	
6.3.2.17	Purification and crystallization of Lactobacillus casei folylpolyglutamate synthetase expressed in Escherichia coli	Lacticaseibacillus casei	
6.3.2.17	Purification and general properties of human folylpolyglutamate synthetase	Homo sapiens	
6.3.2.17	Purification and properties of Lactobacillus casei folylpoly-gamma-glutamate synthetase	Lacticaseibacillus casei	
6.3.2.17	Purification and properties of Neurospora folylpolyglutamate synthetase	Neurospora crassa	
6.3.2.17	Purification, crystallization and preliminary X-ray analysis of Mycobacterium tuberculosis folylpolyglutamate synthase (MtbFPGS)	Mycobacterium tuberculosis	
6.3.2.17	Replacement of the folC gene, encoding folylpolyglutamate synthetase-dihydrofolate synthetase in Escherichia coli, with genes mutagenized in vitro	Escherichia coli	
6.3.2.17	Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia	Homo sapiens	
6.3.2.17	Schedule-dependent synergistic effect of pemetrexed combined with gemcitabine against malignant pleural mesothelioma and non-small cell lung cancer cell lines	Homo sapiens	
6.3.2.17	Structural and functional similarities in the ADP-forming amide bond ligase superfamily: implications for a substrate-induced conformational change in folylpolyglutamate synthetase	Lacticaseibacillus casei	
6.3.2.17	Structural specificity of inhibition of human folylpolyglutamate synthetase by ornithine-containing folate analogs	Homo sapiens	
6.3.2.17	Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP	Mycobacterium tuberculosis	
6.3.2.17	Studies on the substrate specificity of mammalian folylpolyglutamate synthetase	Rattus norvegicus	
6.3.2.17	Submitochondrial localization of the mitochondrial isoform of folylpolyglutamate synthetase in CCRF-CEM human T-lymphoblastic leukemia cells	Homo sapiens	
6.3.2.17	Synthesis of (6R)- and (6S)-5,10-dideazatetrahydrofolate oligo-gamma-glutamates: kinetics of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase	Homo sapiens	
6.3.2.17	Synthesis of L-2-(N-pteroylamino)-3-(N-phosphonoacetyl)aminopropanoic acid as an analogue of the putative phosphorylated intermediate in the gamma-glutamation of folic acid by folylpolyglutamate synthetase	Mus musculus	
6.3.2.17	Synthesis of L-2-(N-pteroylamino)-3-(N-phosphonoacetyl)aminopropanoic acid as an analogue of the putative phosphorylated intermediate in the gamma-glutamation of folic acid by folylpolyglutamate synthetase	Sus scrofa	
6.3.2.17	Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana	Arabidopsis thaliana	
6.3.2.17	The folylpolyglutamate synthetase plastidial isoform is required for postembryonic root development in Arabidopsis	Arabidopsis thaliana	
6.3.2.17	The mitochondrial folylpolyglutamate synthetase gene is required for nitrogen utilization during early seedling development in Aarabidopsis	Arabidopsis thaliana	
6.3.2.17	Tissue-specific expression of functional isoforms of mouse folypoly-gamma-glutamate synthetase: a basis for targeting folate antimetabolites	Mus musculus