3.6.1.17 209912 1H, 13C and 15N backbone of the 19000 kDa diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase from Lupinus angustifolius L. J. Biomol. NMR 16 269-270 2000 Lupinus sp. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10805134&form=6&db=m 3.6.1.17 695301 A diadenosine 5',5''-P1P4 tetraphosphate (Ap4A) hydrolase from Arabidopsis thaliana that is activated preferentially by Mn2+ ions Acta Biochim. Pol. 55 151-160 2008 Arabidopsis thaliana http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18345354&form=6&db=m 3.6.1.17 654523 Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases Biochem. J. 373 635-640 2003 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12697025&form=6&db=m 3.6.1.17 654523 Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases Biochem. J. 373 635-640 2003 Lupinus angustifolius http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12697025&form=6&db=m 3.6.1.17 656173 Analysis of the catalytic and binding residues of the diadenosine tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans by site-directed mutagenesis J. Biol. Chem. 278 4435-4439 2003 Caenorhabditis elegans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12475970&form=6&db=m 3.6.1.17 209902 Binding of zinc (II) to beta-D-fructose 2,6-bisphosphate Biochem. Biophys. Res. Commun. 143 206-211 1987 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3030315&form=6&db=m 3.6.1.17 209898 Bis-(5-guanosyl) tetraphosphatase in rat tissues Biochem. J. 201 405-410 1982 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6282267&form=6&db=m 3.6.1.17 719339 Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability DNA Repair 10 176-187 2011 Caenorhabditis elegans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21111690&form=6&db=m 3.6.1.17 719339 Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability DNA Repair 10 176-187 2011 Caenorhabditis elegans Bristol N2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21111690&form=6&db=m 3.6.1.17 687119 Characterisation of a bis(5-nucleosyl)-tetraphosphatase (asymmetrical) from Drosophila melanogaster Int. J. Biochem. Cell Biol. 39 943-954 2007 Drosophila melanogaster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17344088&form=6&db=m 3.6.1.17 654489 Characterization of active-site residues in diadenosine tetraphosphate hydrolase from Lupinus angustifolius Biochem. J. 357 399-405 2001 Lupinus angustifolius http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11439089&form=6&db=m 3.6.1.17 733346 Chlamydia trachomatis CT771 (nudH) is an asymmetric Ap4A hydrolase Biochemistry 53 214-224 2014 Chlamydia trachomatis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24354275&form=6&db=m 3.6.1.17 209904 Cloning and expression of diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase from Lupinus angustifolius L Biochem. J. 329 313-319 1998 Lupinus sp. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9425114&form=6&db=m 3.6.1.17 654817 Cloning, characterisation and crystallization of a diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans Biochim. Biophys. Acta 1550 27-36 2001 Caenorhabditis elegans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11738085&form=6&db=m 3.6.1.17 733257 Crystal structure of wild-type and mutant human Ap4A hydrolase Biochem. Biophys. Res. Commun. 432 16-21 2013 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23384440&form=6&db=m 3.6.1.17 209911 Diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) hydrolase from tomato (Lycopersicon esculentum cv. Lukullus): Purification, biochemical properties and behaviour during stress Z. Naturforsch. C 51 477-486 1996 Solanum lycopersicum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8810090&form=6&db=m 3.6.1.17 209895 Diguanosinetetraphosphatase from rat liver: Activity on diadenosine tetraphosphate and inhibition by adenosine tetraphosphate Eur. J. Biochem. 50 495-501 1975 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=163189&form=6&db=m 3.6.1.17 209894 Diguanosinetetraphosphate guanosylhydrolase in Artemia salina Biochim. Biophys. Acta 358 117-125 1974 Artemia salina http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4368591&form=6&db=m 3.6.1.17 209896 Dinucleosidasetetraphosphatase in rat liver and Artemia salina Biochim. Biophys. Acta 438 304-309 1976 Artemia salina http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=181087&form=6&db=m 3.6.1.17 209896 Dinucleosidasetetraphosphatase in rat liver and Artemia salina Biochim. Biophys. Acta 438 304-309 1976 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=181087&form=6&db=m 3.6.1.17 209906 Dinucleoside tetraphosphatase from human blood cells: Purification and characterization as a high specific activity enzyme recognized by an anti-rat tetraphosphatase antibody FEBS Lett. 287 85-88 1991 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652465&form=6&db=m 3.6.1.17 209906 Dinucleoside tetraphosphatase from human blood cells: Purification and characterization as a high specific activity enzyme recognized by an anti-rat tetraphosphatase antibody FEBS Lett. 287 85-88 1991 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1652465&form=6&db=m 3.6.1.17 209897 Dinucleosidetetraphosphatase from Ehrlich ascites tumour cells: inhibition by adenosine, guanosine and uridine 5-tetraphosphates Int. J. Biochem. 14 629-634 1982 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6286385&form=6&db=m 3.6.1.17 209900 Dinucleosidetetraphosphatase inhibition by Zn(II) Biochem. Biophys. Res. Commun. 113 717-722 1983 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6307299&form=6&db=m 3.6.1.17 711209 Discovery of inhibitors of lupin diadenosine 5,5-P1,P4-tetraphosphate hydrolase by virtual screening Biochemistry 48 7614-7620 2009 Lupinus angustifolius http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19603790&form=6&db=m 3.6.1.17 657213 Ecto-diadenosine polyphosphate hydrolase activity on human prostasomes Prostate 51 1-9 2002 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11920952&form=6&db=m 3.6.1.17 733091 Elucidating diphosphoinositol polyphosphate function with nonhydrolyzable analogues Angew. Chem. Int. Ed. Engl. 53 7192-7197 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24888434&form=6&db=m 3.6.1.17 733872 Enzymatic characteristics of an ApaH-like phosphatase, PrpA, and a diadenosine tetraphosphate hydrolase, ApaH, from Myxococcus xanthus FEBS Lett. 588 3395-3402 2014 Myxococcus xanthus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25107648&form=6&db=m 3.6.1.17 733872 Enzymatic characteristics of an ApaH-like phosphatase, PrpA, and a diadenosine tetraphosphate hydrolase, ApaH, from Myxococcus xanthus FEBS Lett. 588 3395-3402 2014 Myxococcus xanthus DK 1622 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25107648&form=6&db=m 3.6.1.17 209907 Fluoride is a strong specific inhibitor of (asymmetrical) Ap4A hydrolases FEBS Lett. 262 205-208 1990 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159411&form=6&db=m 3.6.1.17 209907 Fluoride is a strong specific inhibitor of (asymmetrical) Ap4A hydrolases FEBS Lett. 262 205-208 1990 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159411&form=6&db=m 3.6.1.17 209907 Fluoride is a strong specific inhibitor of (asymmetrical) Ap4A hydrolases FEBS Lett. 262 205-208 1990 Cucurbita pepo http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159411&form=6&db=m 3.6.1.17 209907 Fluoride is a strong specific inhibitor of (asymmetrical) Ap4A hydrolases FEBS Lett. 262 205-208 1990 Helianthus sp. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159411&form=6&db=m 3.6.1.17 209907 Fluoride is a strong specific inhibitor of (asymmetrical) Ap4A hydrolases FEBS Lett. 262 205-208 1990 Lupinus sp. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2159411&form=6&db=m 3.6.1.17 710715 Free and ATP-bound structures of Ap4A hydrolase from Aquifex aeolicus V5 Acta Crystallogr. Sect. D 66 116-124 2010 Aquifex aeolicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20124691&form=6&db=m 3.6.1.17 209908 Human placental (asymmetrical) diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase: Purification to homogenity and some properties Protein Expr. Purif. 4 45-51 1993 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8381042&form=6&db=m 3.6.1.17 209913 Isolation and charcterization of diadenosine tetraphosphate (Ap4A) hydrolase from Schizosaccharomyces pombe Biochim. Biophys. Acta 1161 139-148 1993 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8381667&form=6&db=m 3.6.1.17 209893 Isolation, purification, and characterization of P1,P4-diguanosine 5'-tetraphosphate asymmetrical-pyrophosphohydrolase from brine shrimp eggs Biochemistry 4 1568-1575 1965 Artemia salina http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4955726&form=6&db=m 3.6.1.17 209905 Lanterns of firefly Photinus pyralis contain abundant diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity J. Biol. Chem. 270 3706-3709 1995 Photinus pyralis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7876110&form=6&db=m 3.6.1.17 209899 Mitochondrial location of rat liver dinucleoside triphosphatase J. Biol. Chem. 261 2064-2067 1986 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3003092&form=6&db=m 3.6.1.17 733450 Molecular characterization and mutational analysis of recombinant diadenosine 5',5''-P1,P4-tetraphosphate hydrolase from Plasmodium falciparum Biol. Pharm. Bull. 35 1191-1196 2012 Plasmodium falciparum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22791172&form=6&db=m 3.6.1.17 697896 Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain: potential substrates and/or inhibitors of Ap4A hydrolases FEBS J. 276 1546-1553 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19210543&form=6&db=m 3.6.1.17 697896 Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain: potential substrates and/or inhibitors of Ap4A hydrolases FEBS J. 276 1546-1553 2009 Lupinus angustifolius http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19210543&form=6&db=m 3.6.1.17 733563 NPP4 is a procoagulant enzyme on the surface of vascular endothelium Blood 120 4432-4440 2012 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22995898&form=6&db=m 3.6.1.17 209903 Nuclear location of a diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) hydrolase in tomato cells grown in suspension cultures Bot. Acta 110 452-457 1997 Solanum lycopersicum - 3.6.1.17 209910 Regiospecificity of the hydrolysis of diadenosine polyphosphates catalyzed by three specific pyrophosphohydrolases Biochemistry 33 235-240 1994 Lupinus sp. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8286347&form=6&db=m 3.6.1.17 713580 SARS coronavirus protein 7a interacts with human Ap4A-hydrolase Virol. J. 7 31 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20144233&form=6&db=m 3.6.1.17 209914 Selective degradation of 2'-adenylated diadenosine tri- and tetraphosphates, Ap3A and Ap4A, by two specific human dinucleoside polyphosphate hydrolases Arch. Biochem. Biophys. 373 218-224 2000 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10620341&form=6&db=m 3.6.1.17 669427 Structure and substrate-binding mechanism of human Ap4A hydrolase J. Biol. Chem. 280 8471-8481 2005 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15596429&form=6&db=m 3.6.1.17 209909 The green alga Scenedesmus obliquus contains both diadenosine 5',5'''-P1,P4-tetraphosphate (asymmetrical) pyrophosphohyrolase and phosphorylase activities Biochem. J. 300 183-189 1994 Chlorella vulgaris http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8198532&form=6&db=m 3.6.1.17 209909 The green alga Scenedesmus obliquus contains both diadenosine 5',5'''-P1,P4-tetraphosphate (asymmetrical) pyrophosphohyrolase and phosphorylase activities Biochem. J. 300 183-189 1994 Scenedesmus sp. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8198532&form=6&db=m 3.6.1.17 209901 Two low Km hydrolytic activities on dinucleoside 5',5'''-P1,P4-tetraphosphates in rat liver. Characterization as the specific dinucleoside tetraphosphatase and a phosphodiesterase-I-like enzyme J. Biol. Chem. 259 2879-2885 1984 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6321483&form=6&db=m