3.5.4.12 757330 ALR encoding dCMP deaminase is critical for DNA damage repair, cell cycle progression and plant development in rice J. Exp. Bot. 68 5773-5786 2017 Oryza sativa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29186482&form=6&db=m 3.5.4.12 755720 Mechanism of the allosteric regulation of Streptococcus mutans 2-deoxycytidylate deaminase Acta Crystallogr. Sect. D 72 883-891 2016 Streptococcus mutans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27377385&form=6&db=m 3.5.4.12 755720 Mechanism of the allosteric regulation of Streptococcus mutans 2-deoxycytidylate deaminase Acta Crystallogr. Sect. D 72 883-891 2016 Streptococcus mutans ATCC 700610 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27377385&form=6&db=m 3.5.4.12 756103 Spectroscopic and calorimetric assays reveal dependence on dCTP and two metals (Zn2++Mg2+) for enzymatic activity of Schistosoma mansoni deoxycytidylate (dCMP) deaminase Biochim. Biophys. Acta 1865 1326-1335 2017 Schistosoma mansoni http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28807888&form=6&db=m 3.5.4.12 668584 5-Methyldeoxycytidine monophosphate deaminase and 5-methylcytidyl-DNA deaminase activities are present in human mature sperm cells FEBS Lett. 519 128-134 2002 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12023031&form=6&db=m 3.5.4.12 289015 A T4-phage deoxycytidylate deaminase mutant that no longer requires deoxycytidine 5'-triphosphate for activation J. Biol. Chem. 275 12598-12602 2000 Escherichia phage T2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10777550&form=6&db=m 3.5.4.12 289015 A T4-phage deoxycytidylate deaminase mutant that no longer requires deoxycytidine 5'-triphosphate for activation J. Biol. Chem. 275 12598-12602 2000 Tequatrovirus T4 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10777550&form=6&db=m 3.5.4.12 289015 A T4-phage deoxycytidylate deaminase mutant that no longer requires deoxycytidine 5'-triphosphate for activation J. Biol. Chem. 275 12598-12602 2000 Enterobacteria phage T6 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10777550&form=6&db=m 3.5.4.12 289020 A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase Prog. Nucleic Acid Res. Mol. Biol. 39 49-80 1990 Bacillus subtilis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2247612&form=6&db=m 3.5.4.12 289020 A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase Prog. Nucleic Acid Res. Mol. Biol. 39 49-80 1990 Escherichia phage T2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2247612&form=6&db=m 3.5.4.12 289020 A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase Prog. Nucleic Acid Res. Mol. Biol. 39 49-80 1990 Tequatrovirus T4 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2247612&form=6&db=m 3.5.4.12 289020 A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase Prog. Nucleic Acid Res. Mol. Biol. 39 49-80 1990 Enterobacteria phage T6 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2247612&form=6&db=m 3.5.4.12 289020 A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase Prog. Nucleic Acid Res. Mol. Biol. 39 49-80 1990 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2247612&form=6&db=m 3.5.4.12 289020 A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase Prog. Nucleic Acid Res. Mol. Biol. 39 49-80 1990 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2247612&form=6&db=m 3.5.4.12 289020 A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase Prog. Nucleic Acid Res. Mol. Biol. 39 49-80 1990 Equus asinus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2247612&form=6&db=m 3.5.4.12 289020 A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase Prog. Nucleic Acid Res. Mol. Biol. 39 49-80 1990 Herpes simplex virus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2247612&form=6&db=m 3.5.4.12 289020 A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase Prog. Nucleic Acid Res. Mol. Biol. 39 49-80 1990 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2247612&form=6&db=m 3.5.4.12 289020 A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase Prog. Nucleic Acid Res. Mol. Biol. 39 49-80 1990 no activity in Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2247612&form=6&db=m 3.5.4.12 289020 A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase Prog. Nucleic Acid Res. Mol. Biol. 39 49-80 1990 no activity in Salmonella typhimurium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2247612&form=6&db=m 3.5.4.12 289020 A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase Prog. Nucleic Acid Res. Mol. Biol. 39 49-80 1990 Polyomavirus sp. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2247612&form=6&db=m 3.5.4.12 289020 A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase Prog. Nucleic Acid Res. Mol. Biol. 39 49-80 1990 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2247612&form=6&db=m 3.5.4.12 289020 A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase Prog. Nucleic Acid Res. Mol. Biol. 39 49-80 1990 Echinoidea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2247612&form=6&db=m 3.5.4.12 289020 A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase Prog. Nucleic Acid Res. Mol. Biol. 39 49-80 1990 Betapolyomavirus macacae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2247612&form=6&db=m 3.5.4.12 289012 Allosteric modifier and substrate binding of donkey deoxycytidylate aminohydrolase (EC 3.5.4.12) Arch. Biochem. Biophys. 289 19-25 1991 Equus asinus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1898061&form=6&db=m 3.5.4.12 289002 Analysis of competition for substrate sites in an allosteric enzyme with co-operative kinetics. Effects of dAMP and dUMP on donkey spleen deoxycytidylate aminohydrolase Eur. J. Biochem. 137 421-427 1983 Equus asinus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6662104&form=6&db=m 3.5.4.12 670328 Assessment of the effect of phosphorylated metabolites of anti-human immunodeficiency virus and anti-hepatitis B virus pyrimidine analogs on the behavior of human deoxycytidylate deaminase Mol. Pharmacol. 63 105-110 2003 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12488542&form=6&db=m 3.5.4.12 688732 Chloroviruses encode a bifunctional dCMP-dCTP deaminase that produces two key intermediates in dTTP formation J. Virol. 81 7662-7671 2007 Paramecium bursaria Chlorella virus 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17475641&form=6&db=m 3.5.4.12 289019 Correlation between deoxycytidine kinase and deaminase activities and response to therapy with ARA-C J. Cell. Pharmacol. 1 79-85 1990 Homo sapiens - 3.5.4.12 688405 Crystal structures of Streptococcus mutans 2-deoxycytidylate deaminase and its complex with substrate analog and allosteric regulator dCTP x Mg2+ J. Mol. Biol. 377 220-231 2008 Streptococcus mutans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18255096&form=6&db=m 3.5.4.12 289005 Deoxycytidylate deaminase from Bacillus subtilis. Purification, characterization, and physiological function J. Biol. Chem. 253 3536-3542 1978 Bacillus subtilis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=418064&form=6&db=m 3.5.4.12 289005 Deoxycytidylate deaminase from Bacillus subtilis. Purification, characterization, and physiological function J. Biol. Chem. 253 3536-3542 1978 Bacillusphage phiE http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=418064&form=6&db=m 3.5.4.12 289005 Deoxycytidylate deaminase from Bacillus subtilis. Purification, characterization, and physiological function J. Biol. Chem. 253 3536-3542 1978 bacteriophage SP8 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=418064&form=6&db=m 3.5.4.12 289005 Deoxycytidylate deaminase from Bacillus subtilis. Purification, characterization, and physiological function J. Biol. Chem. 253 3536-3542 1978 no activity in Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=418064&form=6&db=m 3.5.4.12 289005 Deoxycytidylate deaminase from Bacillus subtilis. Purification, characterization, and physiological function J. Biol. Chem. 253 3536-3542 1978 no activity in Salmonella typhimurium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=418064&form=6&db=m 3.5.4.12 289005 Deoxycytidylate deaminase from Bacillus subtilis. Purification, characterization, and physiological function J. Biol. Chem. 253 3536-3542 1978 Bacillus subtilis ED40 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=418064&form=6&db=m 3.5.4.12 289004 Deoxycytidylate deaminase from T2-infected Escherichia coli Methods Enzymol. 51 412-418 1978 Escherichia phage T2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=357901&form=6&db=m 3.5.4.12 289004 Deoxycytidylate deaminase from T2-infected Escherichia coli Methods Enzymol. 51 412-418 1978 no activity in Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=357901&form=6&db=m 3.5.4.12 289007 Deoxycytidylate deaminase. Evidence for a new enzyme in cells infected by the virus of Herpes simplex Biochem. J. 143 403-409 1974 Cricetinae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4376945&form=6&db=m 3.5.4.12 289007 Deoxycytidylate deaminase. Evidence for a new enzyme in cells infected by the virus of Herpes simplex Biochem. J. 143 403-409 1974 Herpes simplex virus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4376945&form=6&db=m 3.5.4.12 289008 Deoxycytidylate deaminase. Properties of the enzyme from cultured kidney cells of baby hamster Biochem. J. 141 211-217 1974 Cricetinae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4455201&form=6&db=m 3.5.4.12 288999 Deoxycytidylate deaminase. Purification and some properties of the enzyme isolated from human spleen J. Biol. Chem. 256 6335-6340 1981 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7240207&form=6&db=m 3.5.4.12 712083 Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites? Fundam. Clin. Pharmacol. 25 172-185 2011 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20199587&form=6&db=m 3.5.4.12 711628 DNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new therapeutic targets Br. J. Pharmacol. 158 679-692 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19775280&form=6&db=m 3.5.4.12 209853 Enzymes of pyrimidine deoxyribonucleotide metabolism in Mycoplasma mycoides subsp. mycoides J. Bacteriol. 156 1001-1005 1983 Mycoplasma mycoides http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6139361&form=6&db=m 3.5.4.12 288998 Freezing of dCMP aminohydrolase in the activated conformation by glutaraldehyde J. Mol. Biol. 124 133-145 1978 Equus asinus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=101672&form=6&db=m 3.5.4.12 289013 Hill coefficient ratios give binding ratios of allosteric enzyme effectors; inhibition, activation, and squatting in deoxycytidylate aminohydrolase (EC 3.5.4.12) Arch. Biochem. Biophys. 289 12-18 1991 Equus asinus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1898058&form=6&db=m 3.5.4.12 669680 Human cytomegalovirus requires cellular deoxycytidylate deaminase for replication in quiescent cells J. Gen. Virol. 84 1437-1441 2003 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12771412&form=6&db=m 3.5.4.12 289017 Identification of a site necessary for allosteric regulation in T4-phage deoxycytidylate deaminase Biochemistry 33 2104-2112 1994 Tequatrovirus T4 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8117667&form=6&db=m 3.5.4.12 289017 Identification of a site necessary for allosteric regulation in T4-phage deoxycytidylate deaminase Biochemistry 33 2104-2112 1994 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8117667&form=6&db=m 3.5.4.12 289014 Interaction of the high-affinity inhibitor tetrahydro-dUMP with the allosteric enzyme deoxycytidylate aminohydrolase Arch. Biochem. Biophys. 310 49-53 1994 Equus asinus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8161220&form=6&db=m 3.5.4.12 686248 Involvement of deoxycytidylate deaminase in the response to Sn1-type methylation DNA damage in budding yeast Curr. Biol. 17 R755-R757 2007 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17803923&form=6&db=m 3.5.4.12 289000 Isolation of a Saccharomyces cerevisiae mutant strain deficient in deoxycytidylate deaminase activity and partial characterization of the enzyme J. Bacteriol. 158 644-649 1984 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6373725&form=6&db=m 3.5.4.12 289000 Isolation of a Saccharomyces cerevisiae mutant strain deficient in deoxycytidylate deaminase activity and partial characterization of the enzyme J. Bacteriol. 158 644-649 1984 no activity in Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6373725&form=6&db=m 3.5.4.12 289000 Isolation of a Saccharomyces cerevisiae mutant strain deficient in deoxycytidylate deaminase activity and partial characterization of the enzyme J. Bacteriol. 158 644-649 1984 no activity in Salmonella typhimurium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6373725&form=6&db=m 3.5.4.12 667541 Modifications of deoxycytidine kinase and deaminase activities by docosahexaenoic acid in normal and transformed rat fibroblasts Biochem. Pharmacol. 63 717-723 2002 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11992640&form=6&db=m 3.5.4.12 289016 Modulation of deoxycytidylate deaminase in intact human leukemia cells. Action of 2',2'-difluorodeoxycytidine Biochem. Pharmacol. 44 1819-1827 1992 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1449536&form=6&db=m 3.5.4.12 289011 On the regulation of a bacterial deoxycytidylate deaminase J. Biol. Chem. 246 7755-7758 1971 Lactobacillus acidophilus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5002683&form=6&db=m 3.5.4.12 289011 On the regulation of a bacterial deoxycytidylate deaminase J. Biol. Chem. 246 7755-7758 1971 Staphylococcus aureus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5002683&form=6&db=m 3.5.4.12 288997 Probing the infra-structure of thymidylate synthase and deoxycytidylate deaminase Adv. Enzyme Regul. 22 413-430 1984 Escherichia phage T2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6433661&form=6&db=m 3.5.4.12 288997 Probing the infra-structure of thymidylate synthase and deoxycytidylate deaminase Adv. Enzyme Regul. 22 413-430 1984 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6433661&form=6&db=m 3.5.4.12 289018 Properties of an affinity-column-purified human deoxycytidylate deaminase Biochim. Biophys. Acta 1162 161-170 1993 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8448179&form=6&db=m 3.5.4.12 289003 Reversal of the effect of the allosteric ligands of dCMP-aminohydrolase and stabilization of the enzyme in the T form J. Mol. 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Chem. 247 931-939 1972 Tequatrovirus T4 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4621659&form=6&db=m 3.5.4.12 289009 T2r+ bacteriophage-induced enzymes. I. The purification and properties of deoxycytidylate deaminase J. Biol. Chem. 247 931-939 1972 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4621659&form=6&db=m 3.5.4.12 289010 T2r+ bacteriophage-induced enzymes. II. The subunit structure of deoxycytidylate deaminase J. Biol. Chem. 247 940-945 1972 Escherichia phage T2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4550765&form=6&db=m 3.5.4.12 289010 T2r+ bacteriophage-induced enzymes. II. The subunit structure of deoxycytidylate deaminase J. Biol. Chem. 247 940-945 1972 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4550765&form=6&db=m 3.5.4.12 734322 The first crystal structure of a dTTP-bound deoxycytidylate deaminase validates and details the allosteric-inhibitor binding site J. Biol. Chem. 290 682-690 2015 Cyanophage S-TIM5 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25404739&form=6&db=m 3.5.4.12 667587 Three-dimensional structure of the R115E mutant of T4-bacteriophage 2-deoxycytidylate deaminase Biochemistry 43 13715-13723 2004 Tequatrovirus T4 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15504034&form=6&db=m