3.4.22.53 755619 calpain-1 and calpain-2 The Yin and Yang of synaptic plasticity and neurodegeneration Trends Neurosci. 39 235-245 2016 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26874794&form=6&db=m 3.4.22.53 754896 Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury Neurobiol. Dis. 93 121-128 2016 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27185592&form=6&db=m 3.4.22.53 752437 ENaC activity is regulated by calpain-2 proteolysis of MARCKS proteins Am. J. Physiol. Cell Physiol. 313 C42-C53 2017 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28468944&form=6&db=m 3.4.22.53 752607 Expression and localization of calpain 3 in the submandibular gland of mice Arch. Oral Biol. 70 9-15 2016 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27295390&form=6&db=m 3.4.22.53 755493 Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimers disease mice and correlates with memory deficits in human subjects Sci. Rep. 8 13119 2018 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30177812&form=6&db=m 3.4.22.53 754967 New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis effect of KRAS status Oncotarget 9 9100-9113 2018 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29507677&form=6&db=m 3.4.22.53 754244 Nuclear translocation of calpain-2 mediates apoptosis of hypertrophied cardiomyocytes in transverse aortic constriction rat J. Cell. Physiol. 230 2743-2754 2015 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25820375&form=6&db=m 3.4.22.53 754631 Single-step purification of calpain-1, calpain-2, and calpastatin using anion-exchange chromatography Methods Mol. Biol. 1915 3-11 2019 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30617791&form=6&db=m 3.4.22.53 644024 A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution Genomics 45 175-184 1997 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9339374&form=6&db=m 3.4.22.53 709873 Actin-binding protein-1 interacts with WASp-interacting protein to regulate growth factor-induced dorsal ruffle formation Mol. Biol. Cell 21 186-197 2010 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19910490&form=6&db=m 3.4.22.53 644018 Active site residues in m-calpain: identification by site-directed mutagenesis FEBS Lett. 368 397-400 1995 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7635186&form=6&db=m 3.4.22.53 686159 Altered expression, intracellular distribution and activity of lymphocyte calpain II in Duchenne muscular dystrophy Clin. Chim. Acta 373 82-87 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16815350&form=6&db=m 3.4.22.53 688909 Asymmetric localization of calpain 2 during neutrophil chemotaxis Mol. Biol. Cell 18 795-805 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17192410&form=6&db=m 3.4.22.53 709641 Brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation J. Neurosci. 30 1086-1095 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20089917&form=6&db=m 3.4.22.53 717157 Ca2+-induced release of mitochondrial m-calpain from outer membrane with binding of calpain small subunit and Grp75 Arch. Biochem. Biophys. 507 254-261 2011 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21145877&form=6&db=m 3.4.22.53 644017 Ca2+-induced structural changes in rat m-calpain revealed by partial proteolysis Biochim. Biophys. Acta 1545 245-254 2001 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11342050&form=6&db=m 3.4.22.53 717806 Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes J. Biol. Chem. 285 339-348 2010 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19861418&form=6&db=m 3.4.22.53 708954 Calcium-dependent cleavage of the Na+/Ca2+ exchanger by m-calpain in isolated endoplasmic reticulum J. Biochem. 147 225-235 2010 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19884190&form=6&db=m 3.4.22.53 643979 Calcium-dependent neutral proteases, widespread occurence of a species of protease active at lower concentrations of calcium J. Biochem. 90 889-892 1981 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7031044&form=6&db=m 3.4.22.53 731892 Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation Hum. Cell 25 36-44 2012 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22315009&form=6&db=m 3.4.22.53 681694 Calpain 1 and 2 are required for RNA replication of echovirus 1 J. Virol. 82 1581-1590 2008 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18032503&form=6&db=m 3.4.22.53 687908 Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion J. Cell Biol. 180 957-971 2008 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18332219&form=6&db=m 3.4.22.53 718262 Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes PLoS ONE 5 e15090 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21152086&form=6&db=m 3.4.22.53 687156 Calpain 2 expression pattern and sub-cellular localization during mouse embryogenesis Int. J. Dev. Biol. 52 383-388 2008 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18415939&form=6&db=m 3.4.22.53 718169 Calpain 2 is required for glioblastoma cell invasion: regulation of matrix metalloproteinase 2 Neurochem. Res. 35 1796-1804 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20730561&form=6&db=m 3.4.22.53 708140 Calpain 2 is required for sister chromatid cohesion Chromosoma 119 267-274 2010 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20094891&form=6&db=m 3.4.22.53 732365 Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment J. Neurosci. Res. 90 769-781 2012 Danio rerio http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22183788&form=6&db=m 3.4.22.53 732050 Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma J. Biol. Chem. 287 15458-15465 2012 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427650&form=6&db=m 3.4.22.53 643982 Calpain and calpastatin in porcine retina Biochem. J. 223 47-51 1984 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6093770&form=6&db=m 3.4.22.53 709013 Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration J. Biol. Chem. 284 12447-12458 2009 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19240038&form=6&db=m 3.4.22.53 668358 Calpain inhibition: a therapeutic strategy targeting multiple disease states Curr. Pharm. Des. 12 615-638 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16472152&form=6&db=m 3.4.22.53 709652 Calpain inhibitor SNJ-1945 attenuates events prior to angiogenesis in cultured human retinal endothelial cells J. Ocul. Pharmacol. Ther. 25 409-414 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19857102&form=6&db=m 3.4.22.53 709241 Calpain inhibitors prevent p38 MAPK activation and germ cell apoptosis after heat stress in pubertal rat testes J. Cell. Physiol. 221 296-305 2009 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19598167&form=6&db=m 3.4.22.53 667136 Calpain mediates calcium-induced activation of the Erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: Relevance to Alzheimers disease Am. J. Pathol. 165 795-805 2004 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15331404&form=6&db=m 3.4.22.53 644019 Calpain mutants with increased Ca2+ sensitivity and implications for the role of the C2-like domain J. Biol. Chem. 276 7404-7407 2001 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11102442&form=6&db=m 3.4.22.53 709566 Calpain translocation and activation as pharmacological targets during myocardial ischemia/reperfusion J. Mol. Cell. Cardiol. 49 271-279 2010 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20211186&form=6&db=m 3.4.22.53 686630 Calpain-2 regulation of VEGF-mediated angiogenesis FASEB J. 20 1443-1451 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16816119&form=6&db=m 3.4.22.53 644003 Calpain-calpastatin: a novel, complete calcium-dependent protease system in human spermatozoa Mol. Hum. Reprod. 5 520-526 1999 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10340998&form=6&db=m 3.4.22.53 708781 Calpain-mediated breakdown of cytoskeletal proteins contributes to cholecystokinin-induced damage of rat pancreatic acini Int. J. Exp. Pathol. 90 387-399 2009 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19659897&form=6&db=m 3.4.22.53 668262 Calpain-mediated impairment of Na+/K+-ATPase activity during early reperfusion contributes to cell death after myocardial ischemia Circ. Res. 97 465-473 2005 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16100049&form=6&db=m 3.4.22.53 710518 Calpain-truncated CRMP-3 and -4 contribute to potassium deprivation-induced apoptosis of cerebellar granule neurons Proteomics 9 3712-3728 2009 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19639589&form=6&db=m 3.4.22.53 708416 Calpains: markers of tumor aggressiveness? Exp. Cell Res. 316 1587-1599 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20193680&form=6&db=m 3.4.22.53 644005 Calpains: physiological and pathophysiological significance Pathophysiology 6 91-102 1999 Rattus norvegicus - 3.4.22.53 709031 Calpeptin increases the activity of upstream stimulatory factor and induces high level globin gene expression in erythroid cells J. Biol. Chem. 284 20130-20135 2009 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19491096&form=6&db=m 3.4.22.53 707980 Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis Cancer Res. 69 3755-3763 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19383910&form=6&db=m 3.4.22.53 644011 cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs Biochem. Biophys. Res. Commun. 275 223-227 2000 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10944468&form=6&db=m 3.4.22.53 708582 Characterisation of capn1, capn2-like, capn3 and capn11 genes in Atlantic halibut (Hippoglossus hippoglossus L.): Transcriptional regulation across tissues and in skeletal muscle at distinct nutritional states Gene 453 45-58 2010 Hippoglossus hippoglossus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20093171&form=6&db=m 3.4.22.53 707902 Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion Br. J. Cancer 101 327-334 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19568240&form=6&db=m 3.4.22.53 708960 Characteristic properties of endoplasmic reticulum membrane m-calpain, calpastatin and lumen m-calpain: a comparative study between membrane and lumen m-calpains J. Biochem. 147 765-779 2010 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20123702&form=6&db=m 3.4.22.53 644030 Characterization of calpain II in the retina and photoreceptor outer segments J. Cell Sci. 105 787-798 1993 Bos taurus - 3.4.22.53 687611 Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease J. Biol. Chem. 282 27810-27824 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17650508&form=6&db=m 3.4.22.53 706941 Cloning and characterization of the yak gene coding for calpastatin and in silico analysis of its putative product Acta Biochim. Pol. 57 35-41 2010 Bos mutus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20300663&form=6&db=m 3.4.22.53 643972 Cloning the partial cDNAs of mu-calpain and m-calpain from porcine skeletal muscle Biochimie 75 931-936 1993 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8312396&form=6&db=m 3.4.22.53 643988 Comparison of low and high calcium requiring forms of the calcium-activated neutral protease (CANP) from rabbit skeletal muscle J. Biochem. 95 1661-1670 1984 Oryctolagus cuniculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6088474&form=6&db=m 3.4.22.53 644031 Comparison of the properties of m-calpain from Tilapia and grass shrimp muscles J. Agric. Food Chem. 41 1379-1384 1993 Penaeus monodon http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100232395&form=6&db=m 3.4.22.53 644031 Comparison of the properties of m-calpain from Tilapia and grass shrimp muscles J. Agric. Food Chem. 41 1379-1384 1993 Tilapia sp. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100232395&form=6&db=m 3.4.22.53 644020 Crystal structure of calpain reveals the structural basis for Ca2+-dependent protease activity and a novel mode of enzyme activation EMBO J. 18 6880-6889 1999 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10601010&form=6&db=m 3.4.22.53 644025 Crystallization and X-ray crystallographic analysis of m-calpain, a Ca2+-dependent protease Acta Crystallogr. Sect. D 55 1484-1486 1999 Rattus norvegicus - 3.4.22.53 643974 Different expression patterns for ubiquitous calpains and Capn3 splice variants in monkey ocular tissues Biochim. Biophys. Acta 1519 55-64 2001 Macaca fascicularis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11406271&form=6&db=m 3.4.22.53 667378 Differential influence of proteolysis by calpain 2 and Lp82 on in vitro precipitation of mouse lens crystallins Biochem. Biophys. Res. Commun. 307 558-563 2003 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12893259&form=6&db=m 3.4.22.53 677455 Differential localization of autolyzed calpains 1 and 2 in slow and fast skeletal muscles in the early phase of atrophy Am. J. Physiol. 292 C1723-C1731 2007 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17182728&form=6&db=m 3.4.22.53 732688 Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation PLoS ONE 7 e33468 2012 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22432027&form=6&db=m 3.4.22.53 643971 E-F hand structure-domain of calcium-activated neutral protease (CANP) can bind Ca2+ ions J. Biochem. 101 889-895 1987 Oryctolagus cuniculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3038855&form=6&db=m 3.4.22.53 717628 Effect of calcium lactate on m-calpain activity and protein degradation under oxidising conditions Food Chem. 131 73-78 2012 Sus scrofa - 3.4.22.53 669062 Effect of oxidation, pH, and ionic strength on calpastatin inhibition of mu- and m-calpain J. Anim. Sci. 84 925-937 2006 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16543571&form=6&db=m 3.4.22.53 669060 Effect of pH and ionic strength on mu- and m-calpain inhibition by calpastatin J. Anim. Sci. 83 1370-1376 2005 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15890814&form=6&db=m 3.4.22.53 680394 Effect of postmortem storage on activity of mu- and m-calpain in five bovine muscles J. Anim. Sci. 85 2670-2681 2007 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17565059&form=6&db=m 3.4.22.53 667778 Effects of autolysis on properties of mu- and m-calpain Biochim. Biophys. Acta 1691 91-103 2004 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15110990&form=6&db=m 3.4.22.53 697687 Effects of concentric and repeated eccentric exercise on muscle damage and calpain-calpastatin gene expression in human skeletal muscle Eur. J. Appl. Physiol. 103 323-332 2008 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18340456&form=6&db=m 3.4.22.53 644049 Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway J. Biol. Chem. 275 2390-2398 2000 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10644690&form=6&db=m 3.4.22.53 709126 ERK regulates calpain 2-induced androgen receptor proteolysis in CWR22 relapsed prostate tumor cell lines J. Biol. Chem. 285 2368-2374 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19946123&form=6&db=m 3.4.22.53 687653 Fetuin A stabilizes m-calpain and facilitates plasma membrane repair J. Biol. Chem. 282 35868-35877 2007 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17942392&form=6&db=m 3.4.22.53 709665 Folding transitions in calpain activator peptides studied by solution NMR spectroscopy J. Pept. Sci. 15 404-410 2009 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19378261&form=6&db=m 3.4.22.53 687441 G1-G2 aggrecan product that can be generated by M-calpain on truncation at Ala709-Ala710 is present abundantly in human articular cartilage J. Biochem. 141 469-477 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17261541&form=6&db=m 3.4.22.53 644012 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences Proc. Natl. Acad. Sci. USA 99 16899-16903 2002 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12477932&form=6&db=m 3.4.22.53 644047 Glutamate substitutions at a PKA consensus site are consistent with inactivation of calpain by phosphorylation FEBS Lett. 542 115-118 2003 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12729909&form=6&db=m 3.4.22.53 643985 Human placental calcium activated neutral proteinase: Separation and functional characterization of subunits J. Biosci. 15 427-434 1990 Homo sapiens - 3.4.22.53 644022 Hypoxia-specific upregulation of calpain activity and gene expression in pulmonary artery endothelial cells Am. J. Physiol. 275 L461-L468 1998 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9728040&form=6&db=m 3.4.22.53 644015 Identification of a third ubiquitous calpain species - chicken muscle expresses four distinct calpains Biochim. Biophys. Acta 1261 381-393 1995 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7742367&form=6&db=m 3.4.22.53 643986 Identification of both calpains I and II in nucleated chicken erythrocytes J. Biochem. 103 168-171 1988 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2834353&form=6&db=m 3.4.22.53 717623 Identification of calpastatin, ?-calpain and m-calpain in Atlantic salmon (Salmo salar L.) muscle Food Chem. 125 1091-1096 2011 Salmo salar http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100054036&form=6&db=m 3.4.22.53 707385 Identification of candidate genes involved in endogenous protection mechanisms against acute pancreatitis in mice Biochem. Biophys. Res. Commun. 391 1342-1347 2010 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20026013&form=6&db=m 3.4.22.53 709796 Identification of the new polymorphisms in the promoter region of the CAST gene in cattle Meat Sci. 82 278-283 2009 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20416736&form=6&db=m 3.4.22.53 708389 IGF-I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death Eur. J. Neurosci. 30 975-986 2009 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19723289&form=6&db=m 3.4.22.53 708062 IL-13 downregulates PPAR-gamma/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death Cell. Mol. Life Sci. 67 1465-1476 2010 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20221786&form=6&db=m 3.4.22.53 708046 Interleukin-1alpha treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2 Cell Tissue Res. 340 179-188 2010 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20217136&form=6&db=m 3.4.22.53 643977 Intracellular cellular Ca2+-dependent protease (calpain) and its high-molecular-weight endogenous inhibitor (calpastatin) Adv. Enzyme Regul. 19 407-424 1981 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6278869&form=6&db=m 3.4.22.53 668497 Isoform specific function of calpain 2 in regulating membrane protrusion Exp. Cell Res. 299 179-187 2004 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15302585&form=6&db=m 3.4.22.53 687325 Isolation and characterization of mu-calpain, m-calpain, and calpastatin from postmortem muscle. I. Initial steps J. Anim. Sci. 85 3400-3414 2007 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17878283&form=6&db=m 3.4.22.53 643970 Isolation and sequence analyses of cDNA clones for the large subunits of two isozymes of rabbit calcium-dependent protease J. Biol. Chem. 261 9465-9471 1986 Oryctolagus cuniculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2424911&form=6&db=m 3.4.22.53 699654 Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity J. Neurochem. 108 1237-1250 2009 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19141074&form=6&db=m 3.4.22.53 643983 Large-scale purification of porcine calpain I and calpain II and comparison of proteolytic fragments of their subunits J. Biochem. 95 1759-1766 1984 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6088477&form=6&db=m 3.4.22.53 643983 Large-scale purification of porcine calpain I and calpain II and comparison of proteolytic fragments of their subunits J. Biochem. 95 1759-1766 1984 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6088477&form=6&db=m 3.4.22.53 696327 Limb-girdle muscular dystrophy type 2A can result from accelerated autoproteolytic inactivation of calpain 3 Biochemistry 48 3457-3467 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19226146&form=6&db=m 3.4.22.53 696327 Limb-girdle muscular dystrophy type 2A can result from accelerated autoproteolytic inactivation of calpain 3 Biochemistry 48 3457-3467 2009 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19226146&form=6&db=m 3.4.22.53 685331 Localization of m-calpain and calpastatin and studies of their association in pulmonary smooth muscle endoplasmic reticulum Biochim. Biophys. Acta 1770 1297-1307 2007 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17656025&form=6&db=m 3.4.22.53 708018 m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions Cardiovasc. Res. 85 530-541 2010 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19752040&form=6&db=m 3.4.22.53 685818 m-Calpain is required for preimplantation embryonic development in mice BMC Dev. Biol. 6 3 2006 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16433929&form=6&db=m 3.4.22.53 688496 M-calpain-mediated cleavage of GAP-43 near Ser41 is negatively regulated by protein kinase C, calmodulin and calpain-inhibiting fragment GAP-43-3 J. Neurochem. 101 1539-1551 2007 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17326767&form=6&db=m 3.4.22.53 688496 M-calpain-mediated cleavage of GAP-43 near Ser41 is negatively regulated by protein kinase C, calmodulin and calpain-inhibiting fragment GAP-43-3 J. Neurochem. 101 1539-1551 2007 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17326767&form=6&db=m 3.4.22.53 709927 m-Calpain-mediated cleavage of Na+/Ca2+ exchanger-1 in caveolae vesicles isolated from pulmonary artery smooth muscle Mol. Cell. Biochem. 341 167-180 2010 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20372982&form=6&db=m 3.4.22.53 697162 Mechanical stimulation of C2C12 cells increases m-calpain expression, focal adhesion plaque protein degradation Cell Biol. Int. 32 615-622 2008 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18299214&form=6&db=m 3.4.22.53 644052 Milli-calpain from sea bass (Dicentrarchus labrax) white muscle: purification, characterization of its activity and activation in vitro Mar. Biotechnol. 4 51-62 2002 Dicentrarchus labrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14961288&form=6&db=m 3.4.22.53 707281 Mitochondrial calpain system: an overview Arch. Biochem. Biophys. 495 1-7 2010 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20035707&form=6&db=m 3.4.22.53 707559 Mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria Biochim. Biophys. Acta 1793 1848-1859 2009 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19833151&form=6&db=m 3.4.22.53 643981 Molecular and catalytic characterization of intact heterodimeric and derived monomeric calpains isolated under different conditions from pig polymorphonuclear leukocytes Biochemistry 27 3260-3267 1988 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2839229&form=6&db=m 3.4.22.53 644016 Molecular cloning and bacterial expression of cDNA for rat calpain II 80 kDa subunit Biochim. Biophys. Acta 1216 81-93 1993 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8218419&form=6&db=m 3.4.22.53 644009 Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease Biochemistry 27 8122-8128 1988 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2852952&form=6&db=m 3.4.22.53 709329 Na+/H+ exchanger mediates TNF-alpha-induced hepatocyte apoptosis via the calpain-dependent degradation of Bcl-xL J. Gastroenterol. Hepatol. 24 879-885 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19220664&form=6&db=m 3.4.22.53 732375 New m-calpain substrate-based azapeptide inhibitors J. Pept. Sci. 19 370-376 2013 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23613308&form=6&db=m 3.4.22.53 707044 Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion Am. J. Pathol. 174 436-448 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19147824&form=6&db=m 3.4.22.53 717669 Non-steroidal anti-inflammatory drugs inhibit calpain activity and membrane localization of calpain 2 protease Int. J. Biochem. Cell Biol. 42 2030-2036 2010 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20854926&form=6&db=m 3.4.22.53 643968 Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain Biochem. J. 367 263-269 2002 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12014988&form=6&db=m 3.4.22.53 644029 Overexpression, purification, and characterization of human m-calpain and its active site mutant, m-C105S-calpain, using a baculovirus expression system J. Biochem. 124 957-961 1998 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9792919&form=6&db=m 3.4.22.53 644000 Peptidases play an important role in cataractogenesis: an immunohistochemical study on lenses derived from Shumiya cataract rats Histochem. J. 33 511-521 2002 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12005022&form=6&db=m 3.4.22.53 717969 Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors J. Med. Chem. 53 6326-6336 2010 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20690647&form=6&db=m 3.4.22.53 644044 Potential m-calpain substrates during myoblast fusion Exp. Cell Res. 246 433-442 1999 Oryctolagus cuniculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9925759&form=6&db=m 3.4.22.53 644026 Properties of calpain II from Tilapia muscle Agric. Biol. Chem. 55 339-345 1991 Tilapia sp. - 3.4.22.53 668509 Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens Exp. Eye Res. 76 433-443 2003 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12634108&form=6&db=m 3.4.22.53 708151 Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms Circulation 120 983-991 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19720936&form=6&db=m 3.4.22.53 644032 Purification and characterization of a calcium-activated neutral protease from monkey brain and its action on neuropeptides J. Biochem. 96 775-784 1984 Macaca fuscata http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6094523&form=6&db=m 3.4.22.53 644027 Purification and characterization of m-calpain from the skeletal muscle of the amphibian Rana ridibunda J. Exp. Zool. 269 95-105 1994 Pelophylax ridibundus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8207386&form=6&db=m 3.4.22.53 643980 Purification and immunological characterization of two calcium-activated neutral proteinases from rabbit skeletal muscle Biochim. Biophys. Acta 829 244-252 1985 Oryctolagus cuniculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2581621&form=6&db=m 3.4.22.53 643989 Purification of mu-calpain by a novel affinity chromatography approach. New insight into the mechanism of the interaction of the protease with targets J. Biol. Chem. 270 14576-14581 1995 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7782321&form=6&db=m 3.4.22.53 644028 Recombinant calpain II: improved expression systems and production of a C105A active-site mutant for crystallography Protein Eng. 8 843-848 1995 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8637855&form=6&db=m 3.4.22.53 709087 Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK) J. Biol. Chem. 285 11418-11426 2010 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20150423&form=6&db=m 3.4.22.53 684326 Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity Am. J. Physiol. 293 C1216-C1225 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17596297&form=6&db=m 3.4.22.53 717847 Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages J. Biol. Chem. 286 34830-34838 2011 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21849499&form=6&db=m 3.4.22.53 644045 Spatial and cellular localization of calcium-dependent protease (CDP II) in Allomyces arbuscula J. Cell Sci. 116 1095-1105 2003 Allomyces arbusculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12584252&form=6&db=m 3.4.22.53 670249 Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activation Mol. Cell. Biol. 26 5481-5496 2006 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809781&form=6&db=m 3.4.22.53 695462 Specific knockdown of m-calpain blocks myogenesis with cDNA deduced from the corresponding RNAi Am. J. Physiol. Cell Physiol. 294 C957-C965 2008 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18216163&form=6&db=m 3.4.22.53 707372 Specific regulation of protein phosphatase 2A PR72/B'' subunits by calpain Biochem. Biophys. Res. Commun. 386 676-681 2009 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19555667&form=6&db=m 3.4.22.53 665705 Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP J. Biol. Chem. 281 11214-11224 2006 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16476741&form=6&db=m 3.4.22.53 707365 SUMO modification modulates the activity of calpain-2 Biochem. Biophys. Res. Commun. 384 444-449 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19422794&form=6&db=m 3.4.22.53 644010 Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease J. Biol. Chem. 264 6404-6411 1989 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2539381&form=6&db=m 3.4.22.53 644008 The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium Proc. Natl. Acad. Sci. USA 97 588-592 2000 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10639123&form=6&db=m 3.4.22.53 644046 The purification and characterization of m-calpain from ostrich brain Int. J. Biochem. Cell Biol. 34 337-347 2002 Struthio camelus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11854033&form=6&db=m 3.4.22.53 644051 Transactivation of capn2 by Myogenic Regulatory Factors During Myogenesis J. Mol. Biol. 326 453-465 2003 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12559913&form=6&db=m 3.4.22.53 644053 Transient activation of dihydropteridine reductase by Ca2+-activated proteolysis Zool. Sci. 17 437-443 2000 Ovis aries - 3.4.22.53 709540 TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun N-terminal kinase J. Mol. Biol. 396 858-869 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20070945&form=6&db=m 3.4.22.53 644050 Tumor necrosis factor-a-inducible I.kappa.Ba proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kB activation J. Biol. Chem. 274 787-794 1999 Oryctolagus cuniculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9873017&form=6&db=m 3.4.22.53 643987 Two distinct Ca2+ proteases (calpain I and calpain II) purified concurrently by the same method from rat kidney J. Biol. Chem. 258 8883-8889 1983 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6306001&form=6&db=m 3.4.22.53 688945 Use of recombinant calpain-2 siRNA adenovirus to assess calpain-2 modulation of lung endothelial cell migration and proliferation Mol. Cell. Biochem. 292 69-78 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16733798&form=6&db=m