3.4.21.46 753602 Complement factor D homolog involved in the alternative complement pathway of rock bream (Oplegnathus fasciatus) Molecular and functional characterization and immune responsive mRNA expression analysis Fish Shellfish Immunol. 55 423-433 2016 Oplegnathus fasciatus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27311435&form=6&db=m 3.4.21.46 752442 Complement factor D protects mice from ethanol-induced inflammation and liver injury Am. J. Physiol. Gastrointest. Liver Physiol. 315 G66-G79 2018 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29597356&form=6&db=m 3.4.21.46 754401 Design, synthesis, and preclinical characterization of selective factor D inhibitors targeting the alternative complement pathway J. Med. Chem. 62 4656-4668 2019 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30995036&form=6&db=m 3.4.21.46 752372 Discovery and design of first benzylamine-based ligands binding to an unlocked conformation of the complement factor D ACS Med. Chem. Lett. 9 490-495 2018 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29795765&form=6&db=m 3.4.21.46 754391 Discovery of highly potent and selective small-molecule reversible factor D inhibitors demonstrating alternative complement pathway inhibition in vivo J. Med. Chem. 60 5717-5735 2017 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28621538&form=6&db=m 3.4.21.46 754127 Dynamic regulation of platelet-derived growth factor D (PDGF-D) activity and extracellular spatial distribution by matriptase-mediated proteolysis J. Biol. Chem. 290 9162-9170 2015 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25678707&form=6&db=m 3.4.21.46 753616 Molecular characterization, expression and antimicrobial activity of complement factor D in Megalobrama amblycephala Fish Shellfish Immunol. 89 43-51 2019 Megalobrama amblycephala http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30890434&form=6&db=m 3.4.21.46 752876 Senescent dermal fibroblasts negatively influence fibroblast extracellular matrix-related gene expression partly via secretion of complement factor D Biofactors 45 556-562 2019 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31026383&form=6&db=m 3.4.21.46 755129 Small molecule-induced complement factor D (adipsin) promotes lipid accumulation and adipocyte differentiation PLoS ONE 11 e0162228 2016 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27611793&form=6&db=m 3.4.21.46 732521 Alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl4-induced injury Mol. Immunol. 64 9-17 2015 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25467802&form=6&db=m 3.4.21.46 732521 Alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl4-induced injury Mol. Immunol. 64 9-17 2015 Mus musculus C57BL/6 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25467802&form=6&db=m 3.4.21.46 708533 An immune responsive complement factor D/adipsin and kallikrein-like serine protease (PoDAK) from the olive flounder Paralichthys olivaceus Fish Shellfish Immunol. 27 486-492 2009 Paralichthys olivaceus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19591942&form=6&db=m 3.4.21.46 668289 Analysis of protein absorbed by LDL column (Liposorber) with special reference to complement component factor D Clin. Chim. Acta 342 155-160 2004 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15026276&form=6&db=m 3.4.21.46 699302 Baculovirus is an efficient vector for the transduction of the eye: comparison of baculovirus- and adenovirus-mediated intravitreal vascular endothelial growth factor D gene transfer in the rabbit eye J. Gene Med. 11 382-389 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19263462&form=6&db=m 3.4.21.46 683539 Complement factor D, albumin, and immunoglobulin G anti-band 3 protein antibodies mimic serum in promoting rosetting of malaria-infected red blood cells Infect. Immun. 75 1771-1777 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17261605&form=6&db=m 3.4.21.46 36587 Crystal structure of a complement factor D mutant expressing enhanced catalytic activity [published erratum appears in J Biol Chem 1995 Dec 29;270(52):31414 J. Biol. Chem. 270 24399-24405 1995 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7592653&form=6&db=m 3.4.21.46 668074 Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections Blood 107 4865-4870 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16527897&form=6&db=m 3.4.21.46 708769 Deguelin-an inhibitor to tumor lymphangiogenesis and lymphatic metastasis by down-regulation of vascular endothelial cell growth factor-D in lung tumor model Int. J. Cancer 127 2455-2466 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20162567&form=6&db=m 3.4.21.46 670101 Effects of complement factor D deficiency on the renal disease of MRL/lpr mice Kidney Int. 65 129-138 2004 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14675043&form=6&db=m 3.4.21.46 731071 Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D Acta Crystallogr. Sect. D 70 733-743 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24598742&form=6&db=m 3.4.21.46 709321 Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D J. Exp. Med. 207 29-37 2010 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20038603&form=6&db=m 3.4.21.46 36580 Factor D of the alternative complement pathway Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. ) 5 549-553 1984 Homo sapiens - 3.4.21.46 36582 Human factor D of the alternative complement pathway. Physicochemical characteristics and N-terminal amino acid sequence Biochemistry 18 5082-5087 1979 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=497171&form=6&db=m 3.4.21.46 36584 Human factor D of the alternative complement pathway: purification and characterization J. Immunol. 119 337-342 1977 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=874324&form=6&db=m 3.4.21.46 698194 Identification of platelet-derived growth factor D in human chronic allograft nephropathy Hum. Pathol. 39 393-402 2008 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18187181&form=6&db=m 3.4.21.46 732044 Inhibiting alternative pathway complement activation by targeting the factor D exosite J. Biol. Chem. 287 12886-12892 2012 Macaca fascicularis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22362762&form=6&db=m 3.4.21.46 732044 Inhibiting alternative pathway complement activation by targeting the factor D exosite J. Biol. Chem. 287 12886-12892 2012 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22362762&form=6&db=m 3.4.21.46 36586 Inhibition of degranulation of human polymorphonuclear leukocytes by complement factor D FEBS Lett. 371 300-302 1995 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7556615&form=6&db=m 3.4.21.46 708370 Interleukin 7/interleukin 7 receptor induce c-Fos/c-Jun-dependent vascular endothelial growth factor-D up-regulation: a mechanism of lymphangiogenesis in lung cancer Eur. J. Cancer 45 866-873 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19136250&form=6&db=m 3.4.21.46 670498 Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway Physiol. Genomics 19 131-142 2004 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15238619&form=6&db=m 3.4.21.46 683526 Maternal transfer of complement components C3-1, C3-3, C3-4, C4, C5, C7, Bf, and Df to offspring in rainbow trout (Oncorhynchus mykiss) Immunogenetics 58 168-179 2006 Oncorhynchus mykiss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16550351&form=6&db=m 3.4.21.46 36591 Molecular and functional identification and purification of complement component factor D from urine of patients with chronic renal failure Mol. Immunol. 27 637-644 1990 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2395435&form=6&db=m 3.4.21.46 669356 Molecular dissection of interactions between components of the alternative pathway of complement and decay accelerating factor (CD55) J. Biol. Chem. 280 2569-2578 2005 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15536079&form=6&db=m 3.4.21.46 698902 Novel vascular endothelial growth factor D (VEGF-D) variants with increased biological activity J. Biol. Chem. 284 16037-1648 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19366703&form=6&db=m 3.4.21.46 707940 Platelet-derived growth factor-D contributes to aggressiveness of breast cancer cells by up-regulating Notch and NF-kappaB signaling pathways Breast Cancer Res. Treat. 126 15-25 2011 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20379844&form=6&db=m 3.4.21.46 36581 Preparation of human factor D of the alternative pathway of complement Methods Enzymol. 80 134-143 1981 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6918766&form=6&db=m 3.4.21.46 36592 Purification and properties of human factor D Methods Enzymol. 223 82-97 1993 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8271969&form=6&db=m 3.4.21.46 36590 Purification of human complement factor D from the peritoneal fluid of patients on chronic ambulatory peritoneal dialysis J. Immunol. Methods 138 265-271 1991 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2033278&form=6&db=m 3.4.21.46 36579 Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor Biochemistry 24 1831-1841 1985 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3893537&form=6&db=m 3.4.21.46 697096 Regulation of vascular endothelial growth factor D by orphan receptors hepatocyte nuclear factor-4 alpha and chicken ovalbumin upstream promoter transcription factors 1 and 2 Cancer Res. 68 457-466 2008 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18199540&form=6&db=m 3.4.21.46 708131 Serum vascular endothelial growth factor-D levels in patients with lymphangioleiomyomatosis reflect lymphatic involvement Chest 135 1293-1300 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19420197&form=6&db=m 3.4.21.46 36585 Structural basis of profactor D activation: from a highly flexible zymogen to a novel self-inhibited serine protease, complement factor D EMBO J. 18 804-814 1999 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10022823&form=6&db=m 3.4.21.46 36588 Structure of diisopropyl fluorophosphate-inhibited factor D Acta Crystallogr. Sect. D 53 143-150 1997 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15299948&form=6&db=m 3.4.21.46 718398 Structures of C3b in complex with factors B and D give insight into complement convertase formation Science 330 1816-1820 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21205667&form=6&db=m 3.4.21.46 36589 Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity J. Mol. Biol. 282 1061-1081 1998 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9753554&form=6&db=m 3.4.21.46 651513 Synthesis of factor D by normal human hepatocytes Int. Arch. Allergy Immunol. 122 299-302 2000 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10971122&form=6&db=m 3.4.21.46 36583 The alternative pathway C3/C5 convertase: chemical basis of factor B activation J. Immunol. 123 529-534 1979 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=458145&form=6&db=m 3.4.21.46 732272 The pro-Factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function J. Immunol. 192 5448-5449 2014 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24907377&form=6&db=m 3.4.21.46 695580 Vascular endothelial growth factor D and intratumoral lymphatics as independent prognostic factors in epithelial ovarian carcinoma Anat. Rec. (Hoboken) 292 562-569 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19226617&form=6&db=m 3.4.21.46 710586 Vascular endothelial growth factor-D is correlated with hepatic metastasis from gastric cancer after radical gastrectomy Surgery 146 896-905 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19744460&form=6&db=m