3.4.24.82	proteolytic modification	autocatalytic cleavage, cleavage sites are Lys694-Phe695 and Thr581-Phe582, following incubation at 37°C for 16 h, ADAMTS-4 is detected as isoforms of 68000 Da, 53000 Da and 40000 Da	638962	
3.4.24.82	proteolytic modification	in vivo production of proteolytically active ADAMTS-4 requires removal of the prodomain by a furin-like activity and MMP-mediated removal of a portion of the C-terminal spacer domain	638964