3.6.4.6 medicine diagnosis, HsPex6p mutations are one of the causes of Zellweger syndrome 210580 3.6.4.6 medicine dysfunction of p97 has serious pathological consequences and has been implicated in a variety of cancers and neurodegenerative deseases 688690 3.6.4.6 medicine HsPEX1 is the causative gene for peroxisome-deficiency autosomal recessive disorders like cerebro-hepato-renal Zellweger syndrome, neonatal adrenoleukodystrophy and infantile refsum disease 210581, 210583