3.1.13.4	diagnostics	clinical significance of deadenylases PARN and NOC on the survival in SCC diagnosed patients	751545	
3.1.13.4	medicine	leukemic cells from patients with acute lymphoblastic leukemia and acute myeloid leukemia display altered expression for CNOT6, CNOT6L, CNOT7 deadenylase and poly(A)-specific ribonuclease with most significant alterations for poly(A)-specific ribonuclease and CNOT7 mRNA levels. In acute lymphoblastic leukemia, a significant amount of poly(A)-specific ribonuclease is phosphorylated	728924	
3.1.13.4	additional information	Mg2+ has dual effects on PARN stability, protecting the active site against denaturation, but destabilizing the overall structural stability of the protein	679848	
3.1.13.4	additional information	R3H domain may stabilize PARN by acting as a protector or intermolecular chaperone of the RRM domain	677976	
3.1.13.4	additional information	RRM motif of PARN harbors both poly(A) and cap binding properties, RRM plays an important role in PARN activity, i.e. recognition and dependence on both the cap structure and poly(A) tail during poly(A) hydrolysis. Trp475 plays an essential role in PARN cap recognition, whereas Glu455 and especially Trp456 play auxiliary roles. Cap binding is not essential for the hydrolytic activity of PARN. Cap and RNA-binding sites of the RRM are structurally and functionally separated from each other	680842	
3.1.13.4	additional information	the entire RRM domain not only contributes to the substrate binding and efficient catalysis of PARN, but also stabilizes the overall structures of the protein. p46 contains only one Trp residue (W219), p54 contains two (W219 and W456), and p74 contains six (W219, W456, W474, W526, W531 and W639)	677823