3.4.22.49	diagnostics	measurement of separase proteolytic activity in single living cells by a fluorogenic flow cytometry assay. The assay is used to quantify Separase proteolytic activity in leukemic cell lines and peripheral blood samples from leukemia patients	755097	
3.4.22.49	medicine	due to the oncogenic activity of cohesin protease, separase in human cancer cells, modulation of separase enzymatic activity could constitute a new therapeutic strategy for targeting resistant, separase-overexpressing aneuploid tumors	752988	
3.4.22.49	medicine	the results show that separase might be a tumor supressor gene	680013	
3.4.22.49	molecular biology	data suggest that the co-ordinated expression of separase, securin and Rad21 is fundamental for the developing brain	681037	
3.4.22.49	molecular biology	in Saccharomyces cerevisiae separase it is shown that separase is implicated in a second non-proteolytic pathway: separsae is essential for the activation of Cdc14 phosphatase and thus a broad programme of late mitotic events culminating in mitotic exit and cell division	682065	
3.4.22.49	molecular biology	separase is identified as a key cell cycle component that is required for degranulation	679433	
3.4.22.49	molecular biology	separse is not only required for chromosome segregation but also for meiotic exit	682065	
3.4.22.49	molecular biology	the results indicate that inhibitory phosphorylation of separase plays a critical role in the maintenance of sister chromatid cohesion and genome stability in proliferating postmigratory primordial germ cells	682481	
3.4.22.49	molecular biology	the results show that a fraction of arm cohesin is protected by Sgo1, which prevents cohesin from being removed by the prophase pathway, and that separase is partly activated in nocodazole-arrested cells and removes the arm cohesion protected by Sgo1	681015