1.10.5.1	medicine	an increased risk of breast cancer is associated with the NQ2 I-29 allele. The I-29-containing genotype is significantly correlated with breast cancer under a dominant model. There is a significant association of the I-29/D polymorphism with luminal-like breast cancer but not with HER2-enriched or triple-negative subtypes	764726	
1.10.5.1	medicine	anti-cancer therapy	671708	
1.10.5.1	medicine	estrogen quinones, including estradiol estradiol-3,4-quinone, generated by estrogen metabolism, are thought to be responsible for estrogen-initiated carcinogenesis. NQO2 could be a novel target for prevention of breast cancer initiation	698051	
1.10.5.1	medicine	NQO2 protein level is significantly higher in non-small cell lung cancer tissues as compared with their normal tissues. NQO2 score at clinical stages III and IV is higher than stage I, and there exists a significant correlation between tumor NQO2 expression level and the pathologic T stage	763861	
1.10.5.1	medicine	QR2 inhibitors possibly represent a therapeutic strategy toward the treatment of learning deficits especially observed in the aged brain	712829	
1.10.5.1	medicine	quinone reductase 2 can play important roles in the regulation of catecholamine oxidation processes that may be involved in the etiology of Parkinson disease	698793	
1.10.5.1	medicine	the high NQO2 activity of intraperitoneal ovarian metastases relative to other tissues indicates a potential for tretazicar therapy in the treatment of this disease	686136