3.4.24.B6 degradation MMP-20 processes dentin sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis 669508 3.4.24.B6 medicine critical role of MMPs in the processing and maturation of the dental matrix 668499 3.4.24.B6 medicine first report of a homozygous mutation in the MMP-20 gene, the mutation destroys the splice acceptor sequence at the 3' end of intron 6 encoding the hemopexin domain, the enamel of the subjects' teeth is pigmented, its surface mottled and rough and the enamel layer more opaque than the underlying dentine 669815 3.4.24.B6 medicine study on the hypothesis that MMP-20 is overexpressed in the dentin-enamel junction, dentin-pulp complex components, and carious dentin of patients that head-and-neck radiotherapy. No apparent damage to the dentin-enamel junction microstructure or other dentin-pulp complex components is observed and no statistically significant differences are detected in MMP-20 expression between the irradiated and control groups 753160 3.4.24.B6 additional information MMP-20 acts either directly or indirectly to faciliate the removal of maturation-stage enamel proteins -, 669647 3.4.24.B6 additional information MMP-20 expression is primarly confined to tooth tissue 667722 3.4.24.B6 pharmacology enzyme is a potential target for selective inhibition and inhibitor design 652736