6.2.1.16	ATP + acetoacetate + CoA	-	
6.2.1.16	additional information	primary role of acetoacetate as a substrate in lipogenesis is to promote cholesterol biosynthesis. Regulation of acetoacetyl-CoA synthetase is synchronized with the regulation of cholesterol biosynthesis	
6.2.1.16	additional information	enzyme normally functions in the re-utilization of some of the acetoacetate produced within the mitochondrion as well as that reaching the cytoplasm	
6.2.1.16	additional information	AACS in adipose tissue plays an important role in utilizing ketone bodies for the fatty acid-synthesis during adipose tissue development	
6.2.1.16	additional information	AACS promoter activity is controlled mainly by C/EBP? during adipogenesis	
6.2.1.16	additional information	SlAacS is a bona fide acetoacetyl-CoA synthetase, an AMP-forming acyl-CoA synthetase