3.4.24.65	casein + H2O	degradation	
3.4.24.65	Elastin + H2O	-	
3.4.24.65	Elastin + H2O	degradation	
3.4.24.65	Elastin + H2O	MMP-12 is active against multiple extracellular protein substrates such as elastin, its effect on elastin is central to emphysema in the lung and photoaging of skin, its expression in the skin increases on photodamaged skin and upon aging	
3.4.24.65	Elastin + H2O	a key structural component of the lung extracellular matrix	
3.4.24.65	extracellular matrix protein + H2O	may be required for macrophages to penetrate basement membranes and remodel injured tissue during inflammation	
3.4.24.65	Fibronectin + H2O	degradation	
3.4.24.65	Gelatin + H2O	-	
3.4.24.65	Laminin + H2O	degradation	
3.4.24.65	additional information	able to degrade all components of extracellular matrix