3.4.22.58	additional information	overexpression induces apoptosis	
3.4.22.58	additional information	the enzyme is involved in cytokine activation	
3.4.22.58	additional information	the enzyme is able to induce apoptosis when overexpressed in COS cells	
3.4.22.58	additional information	the production of the enzyme induces the activation of an endogenous 32000 Da putative cysteine protease (CPP32) like caspase	
3.4.22.58	additional information	Ich-3 may mediate apoptosis induced by granzyme B. Ich-3 does not process pro-interleukin-1beta directly but does promote pro-interleukin-1beta processing by ICE. Ich-3 may play a very important role in apoptosis and inflammatory responses and may be an upstream regulator of ICE