3.4.17.21	folyl-poly-gamma-glutamate + H2O	cleavage of the C-terminal glutamate	
3.4.17.21	additional information	enzyme inhibition depresses mossy fiber-CA3 synaptic transmission	
3.4.17.21	additional information	the enzyme interacts with filamin leading to internalization of PMSA into cells in the perinuclear region, overview	
3.4.17.21	additional information	intestinal absorption of polyglutamyl folates involves cleavage of the glutamate side chain by FGCP	
3.4.17.21	additional information	cross-linking of cell surface PSMA with specific antibodies activates the small GTPases RAS and RAC1 and the MAPKs p38 and ERK1/2 in prostate carcinoma LNCaP cells via NF-kappaB activation, overview. Proliferation of LNCaP cells is inducible by interleukin-6, CCL5 or by cross-linking of PSMA	
3.4.17.21	additional information	PSMA is highly homologous to N-acetylated alpha-linked acidic dipeptidase, NAALADase	
3.4.17.21	additional information	PSMA-targeted photodynamic therapy on cytoskeletal networks in prostate cancer cells results in rapid disruption of microtubules (alpha-/beta-tubulin), microfilaments (actin), and intermediate filaments (cytokeratin 8/18) in the cytoplasm of LNCaP cells. The collapse of cytoplasmic microtubules and the later nuclear translocation of alpha-/beta-tubulin are the most dramatic alternation, overview	
3.4.17.21	N-acetyl-alpha L-aspartyl-L-glutamate + H2O	-	
3.4.17.21	N-acetyl-alpha-L-aspartyl-L-glutamate + H2O	-	
3.4.17.21	N-acetyl-alpha-L-aspartyl-L-glutamate + H2O	enzyme inhibition reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion traumatic brain injury