2.4.2.17 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate - 2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate first step in histidine biosynthesis 2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate first step in histidine biosynthesis, enzyme is regulated in a complex allosterical manner, it is a key enzyme is control of the metabolic flux through the pathway 2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate first step in histidine biosynthesis, mechanism of regulation, overview 2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate first enzyme in histidine biosynthetic pathway. ATP-PRT expression plays a major role in regulating the pool of free His and contributes to the exceptional Ni tolerance of hyperaccumulator Alyssum species 2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate first reaction of histidine biosynthesis 2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate - 2.4.2.17 N1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate -