2.1.1.116	additional information	the enzyme is central to the biosynthesis of tetrahydroisoquinoline-derived alkaloids	
2.1.1.116	S-adenosyl-L-homocysteine + (S)-reticuline	-	
2.1.1.116	S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine	-	
2.1.1.116	S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine	the enzyme catalyzes the last step in (S)-reticuline biosynthesis