1.8.1.6 L-cystine + NADH + H+ - 1.8.1.6 additional information enzyme TRP14 not being able to reduce any classical protein disulfide substrates of thioredoxin 1, Trx1. Trx1-mediated L-cystine reduction is inefficient in the presence of other preferred Trx1 substrates whereas, conversely, TRP14 seems to be a more dedicated L-cystine reductase 1.8.1.6 NADH + L-cystine the enzyme may provide reduced sulfhydryl groups involved in the transition of mycelium to yeast form