1.5.3.12 (RS)-canadine + O2 - 1.5.3.12 (RS)-tetrahydrocolumbamine + O2 - 1.5.3.12 (RS)-tetrahydropalmitine + O2 - 1.5.3.12 (RS)-tetrahydropapaverine + O2 - 1.5.3.12 (S)-scoulerine + O2 DBOX does not fully aromatize the C-ring of (S)-scoulerine but instead catalyzes a two-electron oxidation 1.5.3.12 (S)-stylopine + O2 - 1.5.3.12 dihydrochelerythrine + O2 - 1.5.3.12 Dihydromacarpine + O2 terminal step in the formation of benzophenanthridine alkaloids containing methylene dioxy substitutions in ring A and D 1.5.3.12 dihydrosanguinarine + O2 best substrate 1.5.3.12 dihydrosanguinarine + O2 last step in the biogenesis of sanguinarine