1.14.15.6 (20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2 - 1.14.15.6 (22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2 - 1.14.15.6 cholesterol + 2 reduced adrenodoxin + O2 - 1.14.15.6 cholesterol + 6 reduced adrenodoxin + 3 O2 - 1.14.15.6 cholesterol + 6 reduced adrenodoxin + 3 O2 first step in biosynthesis of all steroid hormones 1.14.15.6 cholesterol + 6 reduced adrenodoxin + 3 O2 overall reaction 1.14.15.6 cholesterol + reduced adrenal ferredoxin + O2 - 1.14.15.6 cholesterol + reduced adrenal ferredoxin + O2 first and rate-limiting enzyme in adrenal steroidogenesis 1.14.15.6 cholesterol + reduced ferredoxin + O2 metabolic regulation of enzyme expression, overview 1.14.15.6 cholesterol + reduced ferredoxin + O2 the catalyzed reaction is not the rate-limiting step in steroidogenesis except in placenta which lacks the steroidogenic acute regulatory protein, overview, enzyme deficiency by mutations leads to severe disorders, overview