1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+) 5,10-methylenetetrahydrofolate + NADP+ Rattus norvegicus - 5,10-methenyltetrahydrofolate + NADPH + H+ - 1.5.1.6 formyltetrahydrofolate dehydrogenase 10-formyltetrahydrofolate + NADP+ + H2O Rattus norvegicus - tetrahydrofolate + CO2 + NADPH + H+ - 1.5.1.6 formyltetrahydrofolate dehydrogenase 10-formyltetrahydrofolate + NADP+ + H2O Rattus norvegicus natural substrate tetrahydrofolate + CO2 + NADPH + H+ - 1.5.1.6 formyltetrahydrofolate dehydrogenase 10-formyltetrahydrofolate + NADP+ + H2O Rattus norvegicus recycling of excess 10-formyltetrahydrofolate that is not needed for purine biosynthesis and restoration of the tetrahydrofolate pool, important for formate metabolism by clearing it as CO2 and thus protecting cells from formate intoxication tetrahydrofolate + CO2 + NADPH + H+ - 1.5.1.6 formyltetrahydrofolate dehydrogenase 10-formyltetrahydrofolate + NADP+ + H2O Rattus norvegicus regulatory mechanism to control the in vivo folate pool size tetrahydrofolate + CO2 + NADPH + H+ - 1.5.1.6 formyltetrahydrofolate dehydrogenase 10-formyltetrahydrofolate + NADP+ + H2O Rattus norvegicus disposal of excess one-carbon units, oxidation of one-carbon moieties is regulated by the ratio of formyltetrahydrofolate to tetrahydrofolate in liver, regulation of the proportion of folate present in the tetrahydrofolate form, presumably to make it available for other reactions of one-carbon metabolism tetrahydrofolate + CO2 + NADPH + H+ - 1.5.1.6 formyltetrahydrofolate dehydrogenase 10-formyltetrahydrofolate + NADP+ + H2O Rattus norvegicus folate-dependent metabolism of formate to carbon dioxide tetrahydrofolate + CO2 + NADPH + H+ - 1.5.1.6 formyltetrahydrofolate dehydrogenase 10-formyltetrahydrofolate + NADP+ + H2O Rattus norvegicus a major folate-binding protein of liver cytosol, 10-formyltetrahydrofolate polyglutamates are tightly bound in vivo tetrahydrofolate + CO2 + NADPH + H+ - 1.5.1.6 formyltetrahydrofolate dehydrogenase 10-formyltetrahydropteroylpentaglutamate + NADP+ + H2O Rattus norvegicus - tetrahydropteroylpentaglutamate + CO2 + NADPH - 1.5.1.6 formyltetrahydrofolate dehydrogenase 10-formyltetrahydropteroylpentaglutamate + NADP+ + H2O Rattus norvegicus natural substrate tetrahydropteroylpentaglutamate + CO2 + NADPH -