3.4.24.B6	aggrecan + H2O	cleavage site is Asn341-Phe342	
3.4.24.B6	ameloblastin + H2O	 N-terminal ameloblastin cleavage products of 13, 15, and 17 kDa accumulate in the sheath space throughout the enamel layer	
3.4.24.B6	ameloblastin + H2O	MMP-20 processes ameloblastin during the secretory stage of amelogenesis, cleaves glycosylated recombinant porcine ameloblastin after Pro2, Gln130, Gln139, Arg170, and Ala222. MMP-20 generates the 23-kDa ameloblastin starting at Tyr223, as well as the 17-kDa (Val1-Arg170) and 15-kDa (Val1-Gln130) ameloblastin cleavage products that concentrate in the sheath space during the secretory stage	
3.4.24.B6	amelogenin + H2O	-	
3.4.24.B6	amelogenin + H2O	amelogenin with a proline 41 to threonine mutation is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis	
3.4.24.B6	amelogenin + H2O	amelogenin constitutes more than 90% of enamel extracellular matrix proteins in secretory-stage enamel	
3.4.24.B6	amelogenin + H2O	MMP-20 is involved in amelogenin processing and degradation	
3.4.24.B6	amelogenin + H2O	most of the secreted substrate is cleaved after Ser148 to generate the 20000 Da amelogenin (Met1-Ser148), which in turn is cleaved after Trp45 to yield the tyrosine-rich amelogenin polypeptide (Met1-Trp45) and the 13000 Da amelogenin (Leu46-Ser148)	
3.4.24.B6	amylogenin + H2O	involved in tooth formation	
3.4.24.B6	cartilage oligomeric matrix protein + H2O	100 kDa protein substrate