3.4.22.B14	additional information	the virus can regulate in vivo proteinase activity through self inactivation of PLP-1. The lack of p50 production in cells infected with the mouse hepatitis virus strain JHM may regulate PLP-1 activity differently from MHV-59	
3.4.22.B14	ORF 1a polyprotein + H2O	cleavage in cis and in trans. PLP-1 cleavage activity appears to be optimal when both enzyme and substrate are present as part of polyproteins, as they are in the virus replication cycle	
3.4.22.B14	ORF 1a polyprotein + H2O	the enzyme is involved in processing of ORF 1a polyprotein into mature replicase-related polypeptides	
3.4.22.B14	p28	-	
3.4.22.B14	p65	-