3.4.22.52	alpha-actinin + H2O	-	
3.4.22.52	alpha-spectrin + H2O	-	
3.4.22.52	alpha-spectrin + H2O	mu-calpain is neuroprotective in the early stage of excitotoxic injury. Activation and proteolysis of alpha-spectrin by mu-calpain preceds neuronal damage in the developing cerebral cortex induced by chronic treatament of methylmercury	
3.4.22.52	alpha-spectrin II + H2O	-	
3.4.22.52	alphaII-spectrin + H2O	Fanconi anemia proteins play an important role in maintaining the stability of alphaII-spectrin in the cell by regulating its cleavage by mu-calpain	
3.4.22.52	apoptosis inducing factor + H2O	-	
3.4.22.52	apoptosis inducing factor + H2O	activated mitochondrial calpain 1 within intermembrane space cleaves apoptosis inducing factor (AIF), whereas the activated mitochondrial calpain 1 within the matrix cleaves complex I subunits and metabolic enzymes	
3.4.22.52	apoptosis-inducing factor + H2O	although calpain I cleaves recombinant apoptosis-inducing factor in a cell free system, in intact cells under conditions where endogenous calpain is activated by either N-methyl-D-aspartate or N-methyl-N'-nitro-N-nitrosoguanidine administration, apoptosis-inducing factor is not cleaved	
3.4.22.52	apoptosis-inducing factor + H2O	-	
3.4.22.52	apoptosis-inducing factor + H2O	mitochondrial micro-calpain is the protease responsible for processing apoptosis-inducing factor prior to its release