3.4.17.23	amyloid-beta protein 43 + H2O	ACE2 converts amyloid-beta protein 43 to amyloid-beta protein 42 in mouse brain lysates	
3.4.17.23	angiotensin I + H2O	-	
3.4.17.23	angiotensin I + H2O	ACE2 contributes to the production of angiotensin(1-7) from angiotensin I in proximal straight tubule	
3.4.17.23	angiotensin II + H2O	ACE2 is highly regulated at transcription. ACE2 plays a critical role in regulating the balance between vasoconstrictor and vasodilator effects within the RAS cascade. Angiotensin II may be a stimulus determining cardiac ACE2 gene expression, because either reduction in its levels or prevention of angiotensin II binding to the AT1 receptor increases ACE2 mRNA. ACE2 serves as the cellular entry point for severe acute respiratory syndrome (SARS) virus	
3.4.17.23	angiotensin II + H2O	the uteroplacental location of angiotensin (1-7) and ACE2 in pregnancy suggests an autocrine function of angiotensin(1-7) in the vasoactive regulation that characterizes placentation and establishes pregnancy	
3.4.17.23	angiotensin II + H2O	hepatic production of Ang-(1-7) is catalysed by ACE2	
3.4.17.23	angiotensin II + H2O	the major role of ACE2 in Ang peptides metabolism is the production of Ang-(1-7). ACE2 also participates in the metabolism of other peptides non related to the renin-angiotensin system: apelin-13, neurotensin, kinetensin, dynorphin, [des-Arg9]-bradykinin, and [Lys-des-Arg9]-bradykinin	
3.4.17.23	angiotensin II + H2O	the enzyme is involved in the renin angiotensin system	
3.4.17.23	angiotensin II + H2O	-	
3.4.17.23	angiotensin II + H2O	ACE2, a homologue of ACE, EC 3.4.15.1, converts angiotensin II into Ang(1-7). Ang(1-7) shows vasoprotective effects, serum autoantibodies to ACE2 predispose patients with connective tissue diseases to constrictive vasculopathy, pulmonary arterial hypertension, or persistent digital ischemia