3.2.2.6	cyclic ADP-ribose + H2O	-	
3.2.2.6	additional information	enzyme is involved in the regulation of intracellular concentration of adenosine diphosphoribose	
3.2.2.6	additional information	enzyme may be induced by presence of protein in the culture medium. Low concentrations of sucrose or glucose, 0.1%, casamino acids or some amino acids such as Met, Cys, Phe and Trp strongly repress enzyme synthesis	
3.2.2.6	additional information	CD38 is a NAD+-dependent, multifunctional ectoenzyme that cannot only generate cyclic ADP-ribose from NAD+ but also hydrolyze cyclic ADP-ribose to ADP-ribose and transport cyclic ADP-ribose into cells	
3.2.2.6	additional information	frog CD38 enzyme shows NAD+ glycohydrolase, ADP-ribosyl cyclase, and cyclic ADP-ribosyl hydrolase activities	
3.2.2.6	additional information	the enzyme catalyses the hydrolysis of NAD+ into nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose (cADPR)	
3.2.2.6	NAD+	-	
3.2.2.6	NAD+ + H2O	-	
3.2.2.6	NAD+ + H2O	overall reaction	
3.2.2.6	NAD+ + H2O	bovine CD38/NAD+ glycohydrolase catalyzes the hydrolysis of NAD+ to nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose via a stepwise reaction mechanism