3.2.1.45 beta-glucosylceramide + H2O - 3.2.1.45 D-glucosylceramide + H2O - 3.2.1.45 D-glucosylsphingosine + H2O - 3.2.1.45 glucocerebroside + H2O - 3.2.1.45 glucosylceramide + H2O - 3.2.1.45 glucosyllysosphingosine + H2O - 3.2.1.45 additional information the enzyme catalyses the penultimate step in the breakdown of membrane glycosphingolipids 3.2.1.45 additional information point mutations in glucocerebrosidase can cause Gaucher disease, a common lysosomal storage disease