2.1.1.311	S-adenosyl-L-methionine + cytosine2278 in 25S rRNA	Rcm1 is necessary and sufficient for the formation of a large C2278-methylated subpopulation of ribosomes, both under normal and oxidative stress conditions	
2.1.1.311	S-adenosyl-L-methionine + cytosine2278 in 25S rRNA	the enzyme is responsible for the methylation at cytosine2278 of the 25S ribosomal RNA	
2.1.1.311	S-adenosyl-L-methionine + cytosine2278 in 25S rRNA	the methylated residues m5C2278 stabilizes the structure of 25S rRNA and consequently the association of ribosomal proteins with the large ribosomal subunit