2.1.1.270 additional information in vivo reaction is 4'-O-methylation of isoflavones, in vitro reaction is 7-O-methylation 2.1.1.270 S-adenosyl-L-methionine + (+)-6a-hydroxymaackiain - 2.1.1.270 S-adenosyl-L-methionine + (+)-6a-hydroxymaackiain HMM2 is involved primarily in the biosynthesis of (+)-pisatin