2.1.1.117 S-Adenosyl-L-methionine + (S)-scoulerine - 2.1.1.117 S-Adenosyl-L-methionine + (S)-scoulerine the enzyme is responsible for a late step in the biosynthesis of berberine 2.1.1.117 S-Adenosyl-L-methionine + (S)-scoulerine central role in orotoberberine biosynthesis