1.14.19.3 alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ - 1.14.19.3 alpha-linolenoyl-CoA + ferrocytochrome b5 + O2 + H+ - 1.14.19.3 alpha-linoleoyl-CoA + AH2 + O2 - 1.14.19.3 linoleic acid + AH2 + O2 - 1.14.19.3 linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ - 1.14.19.3 linoleoyl-CoA + AH2 + O2 - 1.14.19.3 linoleoyl-CoA + ferrocytochrome b5 + O2 + H+ - 1.14.19.3 additional information D6D activity in preterm, term, and post-natals is estimated by the 20:3n-6/18:2n-6 ratio 1.14.19.3 additional information delta 6 desaturase (FADS6) is a key bifunctional enzyme desaturating linoleic acid or alpha-linolenic acid, analysis of the molecular mechanism of substrate specificity, overview 1.14.19.3 linoleic acid + AH2 + O2 DELTA6-desaturase reaction is the rate-limiting step in the conversion of linoleic acid and alpha linoleic acids to the longer, more highly unsaturated members of the n-6 and n-3 polyunsaturated fatty acids, metabolic pathway in mammalian cells