1.13.11.34 (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate epoxidation 1.13.11.34 (5Z,8Z,10E,12S,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid + O2 - 1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate - 1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate efficient LTA4 formation of 5LO requires both phosphatidyl choline and coactosin-like protein 1.13.11.34 5-hydroperoxyeicosatetraenoic acid - 1.13.11.34 arachidonate + O2 - 1.13.11.34 arachidonate + O2 hydroperoxidation 1.13.11.34 arachidonate + O2 overall reaction 1.13.11.34 arachidonic acid + O2 - 1.13.11.34 arachidonic acid + O2 first committed step in the synthesis of leukotrienes