1.13.11.27	4-hydroxyphenylpyruvate + O2	-	
1.13.11.27	4-hydroxyphenylpyruvate + O2	enzyme participates in catabolism of tyrosine	
1.13.11.27	4-hydroxyphenylpyruvate + O2	key enzyme involved in tyrosine catabolism, congenital 4-hydroxyphenylpyruvate dioxygenase deficiency is a rare, relatively benign condition known as hereditary type III tyrosinemia	
1.13.11.27	4-hydroxyphenylpyruvate + O2	enzyme is involved in production of homogentisate, the aromatic precursor of all phenylquinones	
1.13.11.27	4-hydroxyphenylpyruvate + O2	hppD is transcriptionally activated by HpdA and repressed by HpdR	
1.13.11.27	4-hydroxyphenylpyruvate + O2	the conversion of 4-hydroxyphenyl-pyruvate to homogentisate involves oxidative decarboxylation, side-chain migration and aromatic hydroxylation in a single catalytic cycle. The 4-HPPD reaction is unusual in that the 2-oxoacid and prime substrate moieties are contained within the same molecule	
1.13.11.27	4-hydroxyphenylpyruvate + O2	second step of oxidative tyrosine catabolism	
1.13.11.27	additional information	HpdR positively regulates hpdA expression through direct binding to the HpdA promoter within a region containing two conserved direct repeat sequences. HpdR-dependent hpdA transcription occurs in the presence of 4-hydroxyphenylpyruvate, tyrosine, and phenylalanine, as well as during starvation