3.4.23.18 chymotrypsinogen A + H2O activation 3.4.23.18 DRVYIHPFHLLVYS + 3 H2O tetradecapeptide renin substrate, the enzyme cleaves the Xaa-pro bond with Xaa being any amino acid 3.4.23.18 FVNQHLCGSHLVEALYLVCGERGFFYTPKA + 3 H2O substrate is the oxidized insulin B chain, primarily cleavage at Leu15-Tyr16 and Phe24-Phe25, and minor cleavage of Tyr16-Leu17, overview 3.4.23.18 additional information the extracellular enzyme pays a role in development of aspergillosis in lung of mammalia, but it is not essential for virulence 3.4.23.18 proangiotensin + H2O the enzyme cleaves the Xaa-pro bond with Xaa being any amino acid 3.4.23.18 trypsinogen + H2O activation by cleavage of a Lys-Pro bond