3.4.22.55	all-spectrin + H2O	-	
3.4.22.55	alpha-all-spectrin + H2O	-	
3.4.22.55	BID + H2O	-	
3.4.22.55	BID + H2O	caspase-2 cleaves BID in response 16 to endoplasmic reticulum stress. Resistance to endoplasmic reticulum stress-induced apoptosis can be conferred by inhibiting caspase-2 activity	
3.4.22.55	Bid + H2O	active caspase-2 cleaves Bid to form tBid, which induces mitochondrial outer membrane permeabilization	
3.4.22.55	caspase-2 + H2O	self-cleavage	
3.4.22.55	caspase-2 + H2O	self-cleavage for activation	
3.4.22.55	CERT + H2O	-	
3.4.22.55	CUX1 + H2O	-	
3.4.22.55	cyclophilin A + H2O	-	
3.4.22.55	DELTANp63 + H2O	-	
3.4.22.55	desmoplakin + H2O	-	
3.4.22.55	DNp63a + H2O	-	
3.4.22.55	elF4B + H2O	-	
3.4.22.55	eukaryotic translation initiation factor 4B + H2O	Asp563 in eukaryotic translation initiation factor 4B is a caspase-2-preferred cleavage site	
3.4.22.55	fatty acid binding protein 5 + H2O	-	
3.4.22.55	golgin-160 + H2O	-	
3.4.22.55	golgin-160 + H2O	caspase-2-specific substrate	
3.4.22.55	HDAC4 + H2O	-	
3.4.22.55	huntingtin + H2O	-	
3.4.22.55	ICAD + H2O	-	
3.4.22.55	MDM-2 + H2O	-	
3.4.22.55	MDM2 + H2O	active caspase-2 cleaves MDM2 to form MDM2 p60, which binds to and stabilizes p53	
3.4.22.55	Mdm2 + H2O	Mdm2 is a key negative regulator of p53	
3.4.22.55	MDM2 + H2O	-	
3.4.22.55	Mdm2 protein + H2O	caspase-2 cleaves and inhibits Mdm2 and thereby promotes the stability of the tumor-suppressor p53	
3.4.22.55	additional information	phenotype of animals deficient in caspase-2: increased number of oocytes at birth, and oocytes are less susceptible to doxorubicin-induced apoptosis. B cells are partially resistant to death induction by granzyme B, accelerated apoptosis of facial motor neurons	
3.4.22.55	additional information	the enzyme is an apoptosis initiator	
3.4.22.55	additional information	caspase 2 is involved in ischemia-reperfusion-induced germ-cell-specific apoptosis	
3.4.22.55	additional information	caspase-2 activation regulates PS-341-induced mitochondrial depolarization and apoptosis, suggesting that caspase-2 can serve as a link between lysosomal and mitochondrial permeabilization	
3.4.22.55	additional information	caspase-2 initiates caspase cascade after trichostatin A treatment and involves the formation of the PIDDosome (a complex of caspase-2-CRADD/RAIDD-PIDD)	
3.4.22.55	additional information	caspase-2 is a substrate for caspase-8 and caspase-3	
3.4.22.55	mouse double minute 2 homolog + H2O	-	
3.4.22.55	myotrophin + H2O	-	
3.4.22.55	pakin + H2O	-	
3.4.22.55	PARP + H2O	-	
3.4.22.55	plakin + H2O	-	
3.4.22.55	procaspase-7 + H2O	activation	
3.4.22.55	profilin 1 + H2O	-	
3.4.22.55	protein kinase Cdelta + H2O	-	
3.4.22.55	PRP31 pre-mRNA processing factor 31 homolog + H2O	-	
3.4.22.55	Rho kinase-2 + H2O	-	
3.4.22.55	ROCK1 + H2O	-	
3.4.22.55	ROCK2 + H2O	-	
3.4.22.55	soluble superoxide dismutase 1 + H2O	-	
3.4.22.55	stathmin 1 + H2O	-	
3.4.22.55	tau protein + H2O	caspase-2 cleavage of tau at Asp314 impairs cognitive and synaptic function in animal and cellular models of tauopathies by promoting the missorting of tau to dendritic spines. The truncation product, DELTAtau314, resists fibrillation and is present at higher levels in brains from cognitively impaired mice and humans with Alzheimer's disease	
3.4.22.55	thioredoxin + H2O	-	
3.4.22.55	tropomyosin 2beta + H2O	-	
3.4.22.55	tropomyosin 3 + H2O	-	
3.4.22.55	Val-Asp-Val-Ala-Asp-7-amido-4-methylcoumarin + H2O	-