3.4.19.3 additional information - 3.4.19.3 additional information the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides 3.4.19.3 additional information diurnal variation and left-right distribution of pyroglutamyl peptidase I activity in the rat brain and retina 3.4.19.3 additional information pyroglutamyl peptidase I levels and their left-right distribution in the rat retina and hypothalamus are influenced by light-dark conditions 3.4.19.3 additional information pyroglutamate and iron regulate the expression of the enzyme 3.4.19.3 additional information enzyme may participate in regulating the levels of seminal thyrotropin-relasing hormone analogues and in mediating sperm death associated with necrozoospermia 3.4.19.3 additional information the enzyme might not be dominantly involved in the degradation of thyrotropin-releasing hormone in rats 3.4.19.3 pyroglutamyl-peptide + H2O the enzyme is able to specifically remove the amino-terminal pyroglutamyl residue protecting proteins or peptides from aminopeptidases 3.4.19.3 thyrotrophin releasing hormone - 3.4.19.3 thyrotrophin releasing hormone the enzyme is proposed to inactivate thyrotrophin releasing hormone in brain extracellular space 3.4.19.3 thyrotrophin-releasing hormone + H2O trypanosomal pyroglutamyl aminopeptidase I is responsible for the abnormally rapid degradation of thyrotrophin-releasing hormone in the circulation of infected rats