3.2.1.207	Glc2Man9GlcNAc2 (G2M9)-protein + H2O	glucosidase II plays a key role in glycoprotein processing in the endoplasmic reticulum. This enzyme trims two alpha-1,3-linked glucose residues, Glcalpha1,3Glc (cleavage 1) and Glcalpha1,3Man (cleavage 2) from high-mannose type Glc2Man9GlcNAc2 (G2M9)-proteins. A crowded milieu that contains bovine serum albumin greatly enhances the second trimming step (cleavage 2), which deglucosylates Glc1Man9GlcNAc2, but not the first trimming step (cleavage 1), which removes the terminal glucose residue from Glc2Man9GlcNAc2	
3.2.1.207	Glc2Man9GlcNAc2 + H2O	-	
3.2.1.207	Glc2Man9GlcNAc2 + H2O	involved in the Calnexin Cycle	
3.2.1.207	Glc2Man9GlcNAc2 + H2O	processing of asparagine-linked oligosaccharides	
3.2.1.207	Glc2Man9GlcNAc2 + H2O	removal of glucose residues allows newly synthesized glycoproteins to interact with calnexin and calreticulin, that are part of the chaperone mechanism	
3.2.1.207	Glc2Man9GlcNAc2 + H2O	i.e. G1M9	
3.2.1.207	GlcMan9GlcNAc2 + H2O	-	
3.2.1.207	GlcMan9GlcNAc2 + H2O	G2M9	
3.2.1.207	additional information	Catalyzes the hydrolysis of the inner two alpha-1,3-linked glucose residues present in all N-linked immature oligosaccharides, associates with and glycosylates the protein CD45, possible role in CD45 regulation	
3.2.1.207	additional information	involved in early glycoprotein biogenesis, catalyzes the hydrolysis of two alpha-1,3-linked glucose residues present on all Asn-linked precursor oligosaccharides	
3.2.1.207	additional information	deletion of the glucosidase II gene in Trypanosoma brucei reveals novel N-glycosylation mechanisms in the biosynthesis of variant surface glycoprotein	
3.2.1.207	additional information	endoplasmic reticulum glucosidase II is required for pathogenicity of Ustilago maydis	
3.2.1.207	additional information	the enzyme is involved in the processing of protein-linked N-glycans in the endoplasmic reticulum of filamentous fungi	
3.2.1.207	additional information	the GTB1 subunit of glucosidase II is required for glycoprotein processing in the endoplasmic reticulum, specifically required for the final glucose-trimming event during normal glycoprotein processing	
3.2.1.207	additional information	glucosidase II is a glycan-processing enzyme that trims two alpha1,3-linked glucose residues from N-glycan on newly synthesized glycoproteins	
3.2.1.207	additional information	glucosidase II is a glycoprotein-processing enzyme that successively cleaves two alpha1,3-linked glucose residues from N-linked oligosaccharides in the endoplasmic reticulum	
3.2.1.207	additional information	the enzyme heterodimer is required to efficiently deglucosylate the physiological substrates G2M9 and G1M9