2.8.3.5 succinyl-CoA + 3-hydroxybutyrate - 2.8.3.5 succinyl-CoA + a 3-oxo acid - 2.8.3.5 succinyl-CoA + a 3-oxo acid ketone bodies, produced mainly in the liver, are an important source of energy for extrahepatic tissues 2.8.3.5 succinyl-CoA + acetoacetate - 2.8.3.5 succinyl-CoA + acetoacetate ping-pong mechanism 2.8.3.5 succinyl-CoA + acetoacetate key enzyme for ketone body utilization, SCOT deficiency causes episodes of severe ketoacidosis 2.8.3.5 succinyl-CoA + acetoacetate essential enzyme in the metabolism of ketone bodies in higher animals, reaction via an enzyme-thioester intermediate 2.8.3.5 succinyl-CoA + acetoacetate involved in the breakdown of ketone bodies in the extrahepatic tissues, mainly heart and skeletal muscle, SCOT catalyzes the conversion of the main ketone body, acetoacetate, into acetoacetyl-CoA, which is subsequently metabolized via citric acid cycle for energy production 2.8.3.5 succinyl-CoA + acetoacetate the activation of acetoacetate to acetoacetyl-CoA by SCOT is essential for use of ketone bodies as an energy source 2.8.3.5 succinyl-CoA + acetoacetate ketolytic enzyme, uniquely involved in complete oxidation of ketone bodies 2.8.3.5 succinyl-CoA + acetoacetate key enzyme in ketone body metabolism 2.8.3.5 succinyl-CoA + acetoacetate liver enzyme: produces a substrate circle between acetoacetyl-CoA and acetoacetate 2.8.3.5 succinyl-CoA + acetoacetate rate determining step of ketolysis in extrahepatic tissues 2.8.3.5 succinyl-CoA + acetoacetate enzyme deficiency leads to ketoacidotic crises and persistent ketosis 2.8.3.5 succinyl-CoA + beta-hydroxybutyrate - 2.8.3.5 succinyl-CoA + beta-hydroxybutyrate essential enzyme in the metabolism of ketone bodies in higher animals