2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt1]-L-serine - 2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine - 2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine the enzyme catalyzes the palmitoylation of Ser209 and Cys77 of Wnt3a 2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine the enzyme catalyzes the palmitoylation of Ser209 and Cys77 of Wnt3a expressed in L cells 2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine the enzyme catalyzes the palmitoylation of the serine corresponding to Ser209 of Wnt3a 2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine Wnt3a is palmitoylated in the endoplasmic reticulum and targeted to exosomes, palmitoylated Wnt3a proteins are found throughout the cyto­sol and at the plasma membrane but not in the nucleus, overview 2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt3]-L-serine - 2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt5a]-L-serine - 2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt5]-L-serine - 2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [WntWg]-L-serine the enzyme catalyzes the palmitoylation of Wnt Wingless or Wg 2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine - 2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine the enzyme catalyzes posttranslational modification of Wnts with palmitoleic acid. PORCN is necessary and sufficient for Wnt acylation. PORCN intimately recognizes the local structure of Wnt around the site of acylation 2.3.1.250 (9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine the enzyme is an essential mediators of Wnt secretion and signaling 2.3.1.250 additional information enzyme Porc functions on the N-terminal 24-amino acid domain (83-106) of Wg, binding of Porc with Wg is essential for its activity 2.3.1.250 additional information PORCN splice variants differ globally in signaling activity