1.5.3.12	(RS)-canadine + O2	-	
1.5.3.12	(RS)-tetrahydrocolumbamine + O2	-	
1.5.3.12	(RS)-tetrahydropalmitine + O2	-	
1.5.3.12	(RS)-tetrahydropapaverine + O2	-	
1.5.3.12	(S)-scoulerine + O2	DBOX does not fully aromatize the C-ring of (S)-scoulerine but instead catalyzes a two-electron oxidation	
1.5.3.12	(S)-stylopine + O2	-	
1.5.3.12	dihydrochelerythrine + O2	-	
1.5.3.12	Dihydromacarpine + O2	terminal step in the formation of benzophenanthridine alkaloids containing methylene dioxy substitutions in ring A and D	
1.5.3.12	dihydrosanguinarine + O2	best substrate	
1.5.3.12	dihydrosanguinarine + O2	last step in the biogenesis of sanguinarine	
1.5.3.12	dihydrosanguinarine + O2	induced in a dose-dependent and time-dependent manner up to 4fold to 14fold, respectively when the cells are treated with jasmonate or with acetylsalicylic acid	
1.5.3.12	dihydrosanguinarine + O2	the enzyme catalyses the last reaction of sanguinarine formation	
1.5.3.12	additional information	one of the enzymes that catalyzes a later step in the biogenesis of benzo(c)phenanthridine alkaloids	
1.5.3.12	additional information	the recombinant enzyme preferentially catalyzes the oxidation of dihydrosanguinarine to sanguinarine but also converts (RS)-tetrahydropapaverine to papaverine and several protoberberine alkaloids to oxidized forms, including (RS)-canadine to berberine